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QuickView for Pargyline (compound)


PubChem
Name: Pargyline
PubChem Compound ID: 4688
Description: A monoamine oxidase inhibitor with antihypertensive properties.
Molecular formula: C11H13N
Molecular weight: 159.228 g/mol
Synonyms:
NCGC00015841-02; NCGC00015841-01; 306-07-0; N-Methyl-N-propargylbenzylamine; N-Benzyl-N-methyl-2-propynylamine hydrochloride; Benzyl-methyl-2-propinylamin [Czech]; SPBio_001257; KBio2_001121; N-Benzyl-N-methyl-2-propyn-1-amine; KBio2_006257.
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DrugBank
Identification
Name: Pargyline
Name (isomeric): DB01626
Drug Type: small molecule
Description: A monoamine oxidase inhibitor with antihypertensive properties.
Synonyms:
N-Benzyl-N-methyl-2-propyn-1-amine; Paragyline; Pargyline chloride; Methylbenzylpropynylamine; N-Methyl-N-2-propynylbenzylamine; Benzyl-methyl-2-propinylamin; Pargyline hydrochloride; Pargylin; Methylbenzylpropynylamine hydrochloride; N-Benzyl-N-methyl-2-propynylamine hydrochloride.
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Brand: Eutonyl, Eutonyl-ten, Supirdyl, Lopac-P-8013, Eudatin
Category: Monoamine Oxidase Inhibitors, Antihypertensive Agents
CAS number: 555-57-7
Pharmacology
Indication: For the treatment of moderate to severe hypertension.
Pharmacology: Pargyline is a monoamine oxidase B (MAO-B) inhibitor with antihypertensive properties. Patients taking pargyline must avoid concurrent consumption of tyramine-containing foods such as bleu cheese and beer, as this can lead to a hypertensive crisis.
Mechanism of Action:
MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. There are two isoforms of monoamine oxidase, MAO-A and MAO-B. MAO-A preferentially deaminates serotonin, melatonin, epinephrine and norepinephrine. MAO-B preferentially deaminates phenyle...
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Affected organisms: Humans and other mammals
Interactions
Food interaction:
Food increases the oral bioavailability by 3-5 fold.
Drug interaction:
PseudoephedrineIncreased arterial pressure
PhenylpropanolamineIncreased arterial pressure
TerbutalineIncreased arterial pressure
FenoterolIncreased arterial pressure
OrciprenalineIncreased arterial pressure
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Targets