QuickView for Paxillin (gene)

Gene Symbol:

PXN Homo sapiens

Full name:

paxillin

Synonyms:

paxillin, testicular tissue protein Li 134

Genomic Location:

Chr 12: 119132640-119187892

Description:

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well a...

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This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_02 ,  CCCAGAG_MIR326 ,  P53_DECAMER_Q2 ,  AACTGGA_MIR145 ,  AREB6_04 ,  GR_Q6_01 ,  AML1_01 ,  GGGYGTGNY_UNKNOWN ,  TITF1_Q3 ,  CAGGTA_AREB6_01 ,  CCTGTGA_MIR513 ,  AREB6_01 ,  GACTGTT_MIR212_MIR132 ,  AML1_Q6 ,  GR_01 ,  AAAYRNCTG_UNKNOWN ,  AGGGCAG_MIR18A ,  ER_Q6_01 ,  GGGTGGRR_PAX4_03 ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-132 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-137

Cytogenetic Map:

12q24.23

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