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QuickView for Pck1 (gene)


Gene Symbol:
PCK1 Homo sapiens Homo sapiens
Full name:
phosphoenolpyruvate carboxykinase 1
Synonyms:
PCKDC, PEPCK-C, PEPCK1, PEPCKC, phosphoenolpyruvate carboxykinase, cytosolic [GTP], PEP carboxykinase, phosphoenolpyruvate carboxykinase 1 (soluble), phosphoenolpyruvate carboxykinase, cytosolic, phosphoenolpyruvate carboxylase, phosphopyruvate carboxylase
Genomic Location:
Chr 20: 55569543-55574922
Description:
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Bos taurus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 20
20q13.31


Transcripts Names
NM_002591
XM_024451888
Protein Names
A8K437
Q9UJD2
Q8TCA3
P35558



GO Molecular Function

phosphoenolpyruvate carboxykinase activity | GDP binding | guanyl ribonucleotide binding | ribonucleoside binding | cation binding | magnesium ion binding | carboxylic acid binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | lyase activity | carbon-carbon lyase activity | catalytic activity | anion binding | purine nucleotide binding | phosphoenolpyruvate carboxykinase (GTP) activity | carboxy-lyase activity | ion binding | organic cyclic compound binding | purine nucleoside binding | purine ribonucleoside triphosphate binding | manganese ion binding | GTP binding | transition metal ion binding | nucleoside binding | purine ribonucleotide binding | organic acid binding | metal ion binding | heterocyclic compound binding | guanyl nucleotide binding | small molecule binding

GO Biological Process

response to acidic pH | response to extracellular stimulus | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | response to nutrient levels | response to cytokine | response to interleukin-1 | cellular response to glucose stimulus | response to lipopolysaccharide | glycerol biosynthetic process | response to hormone | response to dexamethasone | glucose metabolic process | cellular response to tumor necrosis factor | cell differentiation | cellular response to extracellular stimulus | response to fructose | response to drug | cellular chemical homeostasis | glucose homeostasis | polyol metabolic process | cellular response to potassium ion starvation | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | cellular homeostasis | dicarboxylic acid metabolic process | short-chain fatty acid metabolic process | triglyceride metabolic process | response to hypoxia | cellular response to starvation | positive regulation of nitrogen compound metabolic process | response to peptide hormone | tissue development | cellular response to retinoic acid | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | hepaticobiliary system development | epithelium development | cellular response to organonitrogen compound | cellular response to acidic pH | cellular lipid metabolic process | glycerol metabolic process | response to stimulus | monocarboxylic acid metabolic process | carboxylic acid catabolic process | cellular response to xenobiotic stimulus | cellular response to hypoxia | response to stress | alcohol metabolic process | response to peptide | response to glucose | response to starvation | fatty acid catabolic process | response to molecule of bacterial origin | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | response to pH | macromolecule modification | drug catabolic process | regulation of nucleic acid-templated transcription | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | multicellular organism development | protein acetylation | response to activity | antibiotic metabolic process | cellular glucose homeostasis | cellular response to peptide hormone stimulus | response to amino acid | response to purine-containing compound | cellular response to insulin stimulus | lipid metabolic process | regulation of gene expression | cellular response to pH | propionate metabolic process | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | hexose biosynthetic process | positive regulation of cellular metabolic process | liver development | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | response to corticosteroid | response to methionine | regulation of transcription by RNA polymerase II | carbohydrate biosynthetic process | cellular response to cytokine stimulus | biosynthetic process | pyruvate metabolic process | cellular response to glucocorticoid stimulus | hepatocyte differentiation | lipid biosynthetic process | carbohydrate metabolic process | response to xenobiotic stimulus | cellular response to corticosteroid stimulus | cellular response to drug | positive regulation of transcription from RNA polymerase II promoter in response to acidic pH | response to bacterium | cell communication | regulation of cellular metabolic process | oxaloacetate metabolic process | cellular lipid catabolic process | homeostatic process | response to monosaccharide | glycerolipid metabolic process | regulation of RNA metabolic process | response to retinoic acid | drug metabolic process | carboxylic acid metabolic process | response to glucagon | glycerol biosynthetic process from pyruvate | protein metabolic process | propionate catabolic process | response to organic substance | gland development | neutral lipid metabolic process | response to antineoplastic agent | response to insulin | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | hexose metabolic process | cellular response to carbohydrate stimulus | chemical homeostasis | gluconeogenesis | lipid catabolic process | organic substance metabolic process | animal organ development | cellular response to cAMP | cellular response to steroid hormone stimulus | fatty acid metabolic process | response to cAMP | cellular response to dexamethasone stimulus | regulation of transcription, DNA-templated | response to organic cyclic compound | internal protein amino acid acetylation | organic acid metabolic process | cellular protein metabolic process | response to biotic stimulus | developmental process | cellular response to interleukin-1 | cellular protein modification process | cellular response to fructose stimulus | positive regulation of transcription, DNA-templated | short-chain fatty acid catabolic process | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | positive regulation of metabolic process | cellular metabolic process | triglyceride biosynthetic process | response to tumor necrosis factor | cellular response to organic substance | response to carbohydrate | response to steroid hormone | response to interleukin-6 | acylglycerol metabolic process | aging | carbohydrate homeostasis | cellular response to glucagon stimulus | response to other organism | positive regulation of gene expression | response to glucocorticoid | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular