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QuickView for Pclo (gene)


Gene Symbol:
PCLO Homo sapiens Homo sapiens
Full name:
piccolo presynaptic cytomatrix protein
Synonyms:
ACZ, PCH3, protein piccolo, aczonin
Genomic Location:
Chr 7: 82225378-82630133
Description:
The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this g...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus Gallus gallus
External Links:
Entrez Gene
Cytogenetic Map:
chr 7
7q21.11





GO Molecular Function

cation binding | lipid binding | phospholipid binding | anion binding | ion binding | protein binding | calcium ion binding | calcium-dependent phospholipid binding | metal ion binding | profilin binding

GO Biological Process

synaptic vesicle exocytosis | exocytosis | neurotransmitter secretion | intracellular signal transduction | regulation of localization | hormone secretion | establishment of localization | nervous system development | intracellular transport | cellular process | secretion | peptide hormone secretion | establishment of organelle localization | localization | protein transport | chemical synaptic transmission | synapse assembly | macromolecule localization | establishment of localization in cell | regulation of cellular process | organelle localization | cellular component organization | presynapse to nucleus signaling pathway | response to stimulus | cellular localization | secretion by cell | cellular component assembly | cell-cell signaling | insulin secretion | regulation of neurotransmitter levels | synaptic vesicle cycle | system development | multicellular organism development | regulation of hormone levels | organic substance transport | synaptic signaling | peptide transport | vesicle-mediated transport | synapse organization | second-messenger-mediated signaling | establishment of vesicle localization | regulated exocytosis | protein localization to synapse | peptide secretion | cell communication | cyclic-nucleotide-mediated signaling | cAMP-mediated signaling | regulation of exocytosis | anatomical structure development | amide transport | regulation of vesicle-mediated transport | calcium ion regulated exocytosis | regulation of secretion | hormone transport | cytoskeleton organization | establishment of protein localization | signaling | synaptic vesicle localization | protein localization | developmental process | organelle organization | regulation of transport | neurotransmitter transport | signal release | vesicle localization | synaptic vesicle transport | protein secretion | signal transduction | multicellular organismal process

GO Cellular Component

presynaptic active zone cytoplasmic component | cytoskeleton of presynaptic active zone | synapse | cell | cytoplasm | cortical cytoskeleton | intracellular organelle | presynapse | postsynapse | vesicle | presynaptic cytoskeleton | postsynaptic density | extracellular exosome | asymmetric synapse | cytoplasmic region | cell cortex region | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | organelle | postsynaptic specialization | presynaptic active zone | extracellular space | cell periphery | cytoskeleton | intracellular | cell junction