QuickView for Pdgfrb (gene)

Gene Symbol:

PDGFRB Homo sapiens

Full name:

platelet derived growth factor receptor beta

Synonyms:

CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT, platelet-derived growth factor receptor beta, Activated tyrosine kinase PDGFRB, CD140 antigen-like family member B, NDEL1-PDGFRB, PDGF-R-beta, PDGFR-beta, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor, beta polypeptide

Genomic Location:

Chr 5: 149473595-149515615

Description:

The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterod...

View Full Description

The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  AP1_C ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  TGGNNNNNNKCCAR_UNKNOWN ,  OCT1_01 ,  STAT6_02 ,  AAANWWTGC_UNKNOWN ,  LYF1_01 ,  AP1_Q6 ,  FAC1_01 ,  EGR2_01 ,  AP1_Q6_01 ,  FOXO3_01 ,  NFY_Q6_01 ,  AP1FJ_Q2 ,  TATA_C ,  GAGCTGG_MIR337 ,  ACCAAAG_MIR9 ,  NFY_01 ,  IRF_Q6 ,  AP1_Q4 ,  RNGTGGGC_UNKNOWN ,  CEBP_Q3 ,  TTGTTT_FOXO4_01 ,  SREBP_Q3 ,  CTGCAGY_UNKNOWN ,  AP1_Q2 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  OLF1_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-378

Cytogenetic Map:

5q32

search → result