QuickView for Pdx-1 (gene)

Gene Symbol:

PDX1 Homo sapiens

Full name:

pancreatic and duodenal homeobox 1

Synonyms:

GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreas/duodenum homeobox protein 1, IPF-1, IUF-1, glucose-sensitive factor, insulin promoter factor 1, homeodomain transcription factor, insulin upstream factor 1, islet/duodenum homeobox-1, pancreatic-duodenal homeobox factor 1, somatostatin transcription factor 1, somatostatin-transactivating factor 1

Genomic Location:

Chr 13: 27392157-27397394

Description:

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression....

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The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Cytogenetic Map:

13q12.2

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