Name: | pegaspargase |
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PubChem Substance ID: | 3812654 |
Synonyms: |
Pegaspargasa [INN-Spanish]; Asparaginase, reaction product with succinic anhydride, esters with polyethylene glycol, monomethyl ether; 130167-69-0; Oncaspar; Pegaspargasum [INN-Latin]; (Monomethoxypolyethylene glycol succinimidyl)74-L-asparaginase; Pegaspargase; Pegaspargase [USAN:INN]
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Name: | pegaspargase |
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Name (isomeric): | DB00059 |
Drug Type: | biotech |
Synonyms: |
Putative L-asparaginase precursor; L-asparagine amidohydrolase
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Brand: | Oncaspar (Enzon Inc) |
Category: | Antineoplastic Agents |
CAS number: | 130167-69-0 |
Indication: | For treatment of acute lymphoblastic leukemia |
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Pharmacology: |
In a significant number of patients with acute leukemia, the malignant cells are dependent on an exogenous source of asparagine for survival. Normal cells, however, are able to synthesize asparagine and thus are affected less by the rapid depletion produced by treatment with the enzyme asparaginase. Oncaspar exploits a metabolic defect in asparagin...
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Mechanism of Action: | Pegaspargase, more effective than asparaginase, converts asparagine to aspartic acid and ammonia. It facilitates production of oxaloacetate which is needed for general cellular metabolism. Some malignant cells lose the ability to produce asparagine and so the loss of exogenous sources of asparagine leads to cell death. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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