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QuickView for Peginterferon alfa-2a (compound)

PubChem Substance
Name: peginterferon alfa-2a
PubChem Substance ID: 3819816
Interferon alphaA (human leukocyte), mono(N2,N6-dicarboxy-L-lysyl)deriv., diester with alpha-methyl-omega-hydroxypoly(oxy-1,2-ethanediyl; Peginterferon alfa-2a; 198153-51-4; Peginterferon alfa-2a [INN]; Pegasys; 330464-33-0; Ro 25-8310/000
Name: peginterferon alfa-2a
Name (isomeric): DB00008
Drug Type: biotech
Brand: Pegasys, Pegasys (Hoffman-La Roche Inc)
Category: Antineoplastic Agents, Immunomodulatory Agents, Antiviral Agents
CAS number: 198153-51-4
Indication: For treatment of hairy cell leukemia, malignant melanoma, and AIDS-related Kaposi's sarcoma.
Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several ke...
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Mechanism of Action:
Interferon alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). These transphosphorylate themselves and phosphorylate the receptors. The phosphorylated INFAR receptors then bind to Stat1 and Stat2 (signal transducers and activators of transcriptio...
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Half Life: Terminal half life is 80 hours (range 50 to 140 hours).
Affected organisms: Humans and other mammals
Food interaction:
Recommended adequate hydration.
Drug interaction:
TheophyllineInterferon increases the effect and toxicity of theophylline
TelbivudineCo-administration of Peginterferon alpha-2a and Telbivudine may increase the risk of serious peripheral neuropathy.
AminophyllineInterferon increases the effect and toxicity of theophylline
DyphyllineInterferon increases the effect and toxicity of theophylline
OxtriphyllineInterferon increases the effect and toxicity of theophylline