Name: | penciclovir |
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PubChem Compound ID: | 4725 |
Molecular formula: | C10H15N5O3 |
Molecular weight: | 253.258 g/mol |
Synonyms: |
PCV; AIDS093113; C07417; AIDS093114; Penciclovir & Human interferon-.alpha.; 97845-62-0; MB2488; BRL 39123; Adenovir; AIDS070978.
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Name: | penciclovir |
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Name (isomeric): | DB00299 |
Drug Type: | small molecule |
Synonyms: |
Penciclovirum [INN-Latin]; PE2
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Brand: | Denavir |
Category: | Antiviral Agents |
CAS number: | 39809-25-1 |
Indication: | Used to treat recurrent cold sores on the lips and face from various herpesvirus invections. |
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Pharmacology: |
Penciclovir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. The activated drug inhibits the viral DNA polymerase. This impairs the...
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Mechanism of Action: |
Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of...
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Absorption: | Measurable penciclovir concentrations were not detected in plasma or urine of healthy male volunteers (n= 12) following single or repeat application of the 1% cream at a dose of 180 mg penciclovir daily. |
Protein binding: | Less than 20%. |
Biotransformation: | Hepatic |
Half Life: | 2 hours |
Toxicity: | Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia. |
Affected organisms: | Herpes simplex virus |
Drug interaction: |
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