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QuickView for Penciclovir (compound)


PubChem
Name: penciclovir
PubChem Compound ID: 4725
Molecular formula: C10H15N5O3
Molecular weight: 253.258 g/mol
Synonyms:
PCV; AIDS093113; C07417; AIDS093114; Penciclovir & Human interferon-.alpha.; 97845-62-0; MB2488; BRL 39123; Adenovir; AIDS070978.
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DrugBank
Identification
Name: penciclovir
Name (isomeric): DB00299
Drug Type: small molecule
Synonyms:
Penciclovirum [INN-Latin]; PE2
Brand: Denavir
Category: Antiviral Agents
CAS number: 39809-25-1
Pharmacology
Indication: Used to treat recurrent cold sores on the lips and face from various herpesvirus invections.
Pharmacology:
Penciclovir is the active metabolite of the oral product famciclovir. The more favorable results observed with topical penciclovir versus topical acyclovir for the treatment of herpes labialis may be due to the longer intracellular half-life of penciclovir in HSV-infected cells. The activated drug inhibits the viral DNA polymerase. This impairs the...
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Mechanism of Action:
Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. The intracellular triphosphate of...
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Absorption: Measurable penciclovir concentrations were not detected in plasma or urine of healthy male volunteers (n= 12) following single or repeat application of the 1% cream at a dose of 180 mg penciclovir daily.
Protein binding: Less than 20%.
Biotransformation: Hepatic
Half Life: 2 hours
Toxicity: Symptoms of overdose include headache, abdominal pain, increased serum lipase, nausea, dyspepsia, dizziness, and hyperbilirubinemia.
Affected organisms: Herpes simplex virus
Interactions
Drug interaction:
AttapulgiteThe multivalent agent decreases the effect of penicillamine
KaolinThe multivalent agent decreases the effect of penicillamine
DigoxinThe multivalent agent decreases the effect of penicillamine
IronThe multivalent agent decreases the effect of penicillamine
AluminiumThe multivalent agent decreases the effect of penicillamine

Targets