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QuickView for Pentamidine (compound)
PubChem
| Name: | Pentamidine |
|---|---|
| PubChem Compound ID: | 359323 |
| Description: | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. |
| Molecular formula: | C21H30N4O6S |
| Molecular weight: | 466.552 g/mol |
| Synonyms: |
DivK1c_000389; Spectrum_000750; KBio2_003798; 140-64-7; KBio2_001230; KBio1_000389; SMR000059147; KBio2_006366; Prestwick0_000553; Pentamidine isethionate.
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DrugBank
Identification
| Name: | Pentamidine |
|---|---|
| Name (isomeric): | DB00738 |
| Drug Type: | small molecule |
| Description: | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. |
| Synonyms: |
4, 4'-Diamidinodiphenoxypentane; Pentamide; Pentamidine Isethionate; PNT; 1,3-bis(4-amidinophenoxy)pentane
|
| Brand: | Pneumopent, Pentam, NebuPent, Pentacarinat, Pentam 300 |
| Category: | Trypanocidal Agents, Antiprotozoal Agents, Antifungal Agents |
| CAS number: | 100-33-4 |
Pharmacology
| Indication: | For the treatment of pneumonia due to <i>Pneumocystis carinii</i>. |
|---|---|
| Pharmacology: |
Pentamidine is an antiprotozoal agent. It is an aromatic diamidine, and is known to have activity against Pneumocystis carinii. The exact nature of its antiprotozoal action is unknown. in vitro studies with mammalian tissues and the protozoan Crithidia oncopelti indicate that the drug interferes with nuclear metabolism producin...
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| Mechanism of Action: | The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins. |
| Absorption: | Absorbed poorly through the gastrointestinal tract and is usually administered parenterally. |
| Protein binding: | 69% |
| Biotransformation: | Hepatic. |
| Half Life: | 9.1-13.2 hours |
| Toxicity: | Symptoms of overdose include pain, nausea, anorexia, hypotension, fever, rash, bad taste in mouth, confusion/hallucinations, dizziness, and diarrhea. |
| Affected organisms: | Pneumocystis carinii |
Interactions
| Drug interaction: |
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Targets
Enzymes
