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QuickView for Pentoxifylline (compound)


PubChem
Name: Pentoxifylline
PubChem Compound ID: 4740
Description: A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
Molecular formula: C13H18N4O3
Molecular weight: 278.307 g/mol
Synonyms:
3,7-Dimethyl-1-(5-oxohexyl)xantine; Trental (TN); Pentoxifilina [INN-Spanish]; 3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione; AIDS-001608; KBio2_001924; Pentoxyphyllin; EHT 0201; 1-(5-Oxohexyl)-3,7-dimethylxanthine; Pentoxiphylline.
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DrugBank
Identification
Name: Pentoxifylline
Name (isomeric): DB00806
Drug Type: small molecule
Description: A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
Synonyms:
EHT0201
Brand: Pentoxyphylline, Pentoxiphyllium, Rentylin, Pentoxifyllin, Pentoxyfylline, Torental, Azupentat, Durapental, Vazofirin, Oxpentifylline, Pentoxil, Dimethyloxohexylxanthine, Trental, PENTOXYPHYLINE
Category: Hemorrheologic Agents, Radiation-Protective Agents, Vasodilator Agents, Phosphodiesterase Inhibitors, Hematologic Agents, Free Radical Scavengers, Platelet Aggregation Inhibitors
CAS number: 6493-05-6
Pharmacology
Indication: For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs.
Pharmacology: Pentoxifylline, a synthetic dimethylxanthine derivative structurally related to theophylline and caffeine, is used in the treatment of peripheral vascular diseases and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy.
Mechanism of Action:
Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. It...
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Protein binding: 70%
Route of elimination: Excretion is almost totally urinary; the main biotransformation product is Metabolite V. Essentially no parent drug is found in the urine.
Half Life: 0.4-0.8 hours
Toxicity: LD50=1385 mg/kg(orally in mice)
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to reduce irritation. Limit caffeine intake.
Drug interaction:
OxtriphyllinePentoxifylline increases the effect and toxicity of theophylline
AcenocoumarolPentoxifylline may increase the anticoagulant effect of acenocoumarol.
WarfarinPentoxifylline may increase the anticoagulant effect of warfarin.
DicumarolPentoxifylline may increase the anticoagulant effect of dicumarol.
AnisindionePentoxifylline may increase the anticoagulant effect of anisindione.
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