Peptidase S1A, chymotrypsin family QuickView

Description:: This group of serine peptidases and non-peptidase homologues belong to the MEROPS peptidase family S1, subfamily S1A (chymotrypsin subfamily, clan PA(S)). The type example being chymotrypsin A from Bos taurus (Bovine).Members of the chymotrypsin family may occasionally function intracellularly(for example, the intracellular digestion of bacteria in neutrophils), butmost function extracellularly, for example in roles such as food digestion, fibrinolysis and complement activation.The essential catalytic unit of the chymotrypsin family is around 220 amino acids in length, although the protein may be extended at theN terminus with unrelated sequences, often containing modules. They arerarely extended at the C terminus: exceptions include acrosin, complement component C2, and coagulation factor X, which has a 16 residue extensionthat is removed upon activation.