QuickView for Per2 (gene)

Gene Symbol:

PER2 Homo sapiens

Full name:

period circadian regulator 2

Synonyms:

FASPS, FASPS1, period circadian protein homolog 2, circadian clock protein PERIOD 2, hPER2, period 2, period circadian clock 2, period circadian protein 2, period homolog 2

Genomic Location:

Chr 2: 238817418-238861946

Description:

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but ...

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This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GABP_B ,  ATAAGCT_MIR21 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  NFAT_Q6 ,  CATTGTYY_SOX9_B1 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TTAYRTAA_E4BP4_01 ,  OCT_C ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  CEBP_01 ,  RFX1_02 ,  TTCYRGAA_UNKNOWN ,  AR_01 ,  GTTTGTT_MIR495 ,  CREBP1_01 ,  MGGAAGTG_GABP_B ,  TGCCAAR_NF1_Q6 ,  NRF2_Q4 ,  TTGTTT_FOXO4_01 ,  SCGGAAGY_ELK1_02 ,  CTGAGCC_MIR24 ,  GTGGGTGK_UNKNOWN ,  PAX2_02 ,  FREAC4_01 ,  PAX4_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

2q37.3

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