Name: | perflutren |
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PubChem Compound ID: | 6432 |
Molecular formula: | C3F8 |
Molecular weight: | 188.019 g/mol |
Synonyms: |
MRX-115; FC 218; FS069; Freon 218; Definity; Definity (TN); HFC 218; UN 2424; OCTAFLUOROPROPANE; FC 218 (refrigerant).
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Name: | perflutren |
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Name (isomeric): | DB00556 |
Drug Type: | small molecule |
Brand: | Perfluoropropane, Freon 218, Genetron 218, Perflutren [USAN], Propane, octafluoro-, Perfluoropropaneminimum, Definity, Perfluoropropane 99+%, Octafluoropropane |
Category: | Ultrasound contrast agent, Contrast Media |
CAS number: | 76-19-7 |
Indication: | Use in patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border. |
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Pharmacology: |
Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. It provide contrast enhancement of the endocardial borders during echocardiography. The perflutren lipid microspheres exhibit lower acous...
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Mechanism of Action: |
Perflutren is comprised of gas-filled microspheres that are injected or infused into the body. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultrasound machine. The difference in density between the gas-filled bubbles and the blood around them creates an increased level of contrast visible in the ...
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Biotransformation: | OFP is not metabolized. The phospholipid components of the microspheres are thought to be metabolized to free fatty acids. |
Half Life: | The mean half-life of OFP in blood 1.9 minutes |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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