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QuickView for Phenylpropanolamine (compound)


PubChem
Name: Phenylpropanolamine
PubChem Compound ID: 10080695
Description: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
Molecular formula: C9H13NO
Molecular weight: 163.161 g/mol
DrugBank
Identification
Name: Phenylpropanolamine
Name (isomeric): DB00397
Drug Type: small molecule
Description: A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
Synonyms:
PPA; (+-)-Phenylpropanolamine; (+/-)-Norephedrin
Brand: Naldecon, Dexatrim, Rhymed, Myminic, Triaminic, Phenoxine, Nolex, Partuss, Codimal, Acutrim, Guaipax, ULR, Ami-Tex, Snaplets, Despec, Phenylfenesin, Conex, Propagest, Gentab, Vanex, Dura-Vent, Phenyldrine, Contuss, Rhindecon, Entex
Brand name mixture:
Tri-Anamine Expect Antihist Decong Syrup(Guaifenesin + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate), Entex La(Guaifenesin + Phenylpropanolamine Hydrochloride), Coricidin D Long Acting Tab(Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride), Caldomine Dh Adulte(Hydrocodone Bitartrate + Pheniramine Maleat...
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Category: Adrenergic alpha-Agonists, Sympathomimetics, Appetite Depressants, Nasal Decongestants
CAS number: 14838-15-4
Pharmacology
Indication: For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
Pharmacology:
Phenylpropanolamine (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Phenylpropanolamine is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing phenylpropano...
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Mechanism of Action:
Phenylpropanolamine acts directly on alpha- and, to a lesser degree, beta-adrenergic receptors in the mucosa of the respiratory tract. Stimulation of alpha-adrenergic receptors produces vasoconstriction, reduces tissue hyperemia, edema, and nasal congestion, and increases nasal airway patency. PPA indirectly stimulates beta-receptors, producing tac...
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Absorption: Reduced bioavailability (about 38%) from gastrointestinal tract because of first pass metabolism by monoamine oxidase in the stomach and liver.
Biotransformation: Hepatic
Half Life: 2.1 to 3.4 hours.
Toxicity: May induce ventricular extrasystoles and short paroxysms of ventricular tachycardia, a sensation of fullness in the head and tingling of the extremities; LD50=1490mg/kg (orally in rat)
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Limit caffeine intake.
Take without regard to meals.
Drug interaction:
PhenelzineIncreased arterial pressure
MesoridazineDecreased anorexic effect, may increase psychotic symptoms
ChlorpromazineDecreased anorexic effect, may increase psychotic symptoms
AlseroxylonIncreased arterial pressure
AmoxapineThe tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of phenylpropanolamine.
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