QuickView for Phospholipase C beta (gene)

Gene Symbol:

PLCB4 Homo sapiens

Full name:

phospholipase C beta 4

Synonyms:

ARCND2, PI-PLC, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate, PLC-beta-4, dJ1119D9.2 (Phopholipase C, beta 4 (1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 4)), inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphoinositidase C, phosphoinositide phospholipase C-beta-4, triphosphoinositide phosphodiesterase

Genomic Location:

Chr 20: 9024932-9409463

Description:

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different is...

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The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTGCCAT_MIR183 ,  GGGCATT_MIR365 ,  TGCAAAC_MIR452 ,  GTGCCAA_MIR96 ,  AATGTGA_MIR23A_MIR23B ,  CCTGCTG_MIR214

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-183 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-378

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Cytogenetic Map:

20p12.3-p12.2

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