QuickView for Phosphopyruvate Hydratase (gene)
- Gene Symbol:
- ENO1
Homo sapiens - Full name:
- enolase 1
- Synonyms:
- ENO1L1, HEL-S-17, MPB1, NNE, PPH, alpha-enolase, c-myc promoter-binding protein-1, 2-phospho-D-glycerate hydro-lyase, MYC promoter-binding protein 1, alpha enolase like 1, enolase 1, (alpha), enolase-alpha, epididymis secretory protein Li 17, non-neural enolase, phosphopyruvate hydratase, plasminogen-binding protein, tau-crystallin
- Genomic Location:
- Chr 1: 8843650-8861367
- Description:
-
This gene encodes alpha-enolase, one of three enolase isoenzymes found in mammals. Each isoenzyme is a homodimer composed of 2 alpha, 2 gamma, or 2 beta subunits, and functions as a glycolytic enzyme. Alpha-enolase in addition, functions as a structural lens protein (tau-crystallin) in the monomeric form. Alternative splicing of this gene results i...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGANTCA_AP1_C , TGANNYRGCA_TCF11MAFG_01 , ATF4_Q2 , AP1_Q6 , NFE2_01 , AP1_01 , BACH2_01 , HIF1_Q5 , NRF2_Q4 , BACH1_01
- Cytogenetic Map:
-
1p36.23
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | GTPase binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | cadherin binding | cation binding | magnesium ion binding | enzyme binding | nucleic acid binding | hydro-lyase activity | lyase activity | catalytic activity | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | ion binding | organic cyclic compound binding | cell adhesion molecule binding | transcription regulatory region sequence-specific DNA binding | protein binding | protein homodimerization activity | double-stranded DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | phosphopyruvate hydratase activity | metal ion binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | purine ribonucleotide metabolic process | regulation of muscle system process | purine ribonucleoside monophosphate biosynthetic process | response to virus | nucleoside phosphate catabolic process | positive regulation of ATP metabolic process | glycolytic process | regulation of programmed cell death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | glucose metabolic process | nicotinamide nucleotide biosynthetic process | generation of precursor metabolites and energy | organophosphate catabolic process | positive regulation of phosphate metabolic process | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | nucleotide metabolic process | negative regulation of signaling | NADH regeneration | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | purine nucleotide biosynthetic process | negative regulation of apoptotic process | regulation of proteolysis | nucleoside triphosphate metabolic process | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | carbohydrate catabolic process | negative regulation of cellular metabolic process | negative regulation of apoptotic signaling pathway | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | positive regulation of protein processing | response to stimulus | purine nucleotide metabolic process | monocarboxylic acid metabolic process | positive regulation of protein metabolic process | regulation of plasminogen activation | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway | cellular nitrogen compound biosynthetic process | positive regulation of plasminogen activation | positive regulation of proteolysis | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | negative regulation of metabolic process | cofactor metabolic process | regulation of protein processing | cellular biosynthetic process | nucleobase-containing compound catabolic process | nucleotide biosynthetic process | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | NADH metabolic process | response to external biotic stimulus | ATP biosynthetic process | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of growth | regulation of cellular response to hypoxia | coenzyme biosynthetic process | phosphorus metabolic process | ribonucleoside monophosphate biosynthetic process | regulation of muscle contraction | regulation of intrinsic apoptotic signaling pathway | regulation of gene expression | NAD biosynthetic process | organophosphate metabolic process | hexose biosynthetic process | nucleotide phosphorylation | positive regulation of cellular metabolic process | cofactor biosynthetic process | positive regulation of ATP biosynthetic process | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing small molecule metabolic process | carbohydrate biosynthetic process | biosynthetic process | pyruvate metabolic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | purine ribonucleotide biosynthetic process | carbohydrate metabolic process | nucleotide catabolic process | nucleoside triphosphate biosynthetic process | regulation of apoptotic signaling pathway | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of protein metabolic process | aromatic compound catabolic process | regulation of RNA metabolic process | negative regulation of cell growth | drug metabolic process | carboxylic acid metabolic process | pyridine nucleotide biosynthetic process | glycolytic process through glucose-6-phosphate | DNA-binding transcription factor activity | regulation of growth | nucleoside diphosphate metabolic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | metabolic process | regulation of RNA biosynthetic process | hexose metabolic process | oxidation-reduction process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | gluconeogenesis | nucleobase-containing compound metabolic process | positive regulation of muscle contraction | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | glycolytic process through fructose-6-phosphate | ATP generation from ADP | regulation of ATP metabolic process | regulation of phosphate metabolic process | transcription, DNA-templated | pyruvate biosynthetic process | ADP metabolic process | regulation of cell communication | positive regulation of protein maturation | negative regulation of signal transduction | regulation of transcription, DNA-templated | ribose phosphate biosynthetic process | organic acid metabolic process | glucose catabolic process | cellular macromolecule biosynthetic process | response to biotic stimulus | nicotinamide nucleotide metabolic process | regulation of cell growth | NAD metabolic process | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | canonical glycolysis | heterocycle metabolic process | positive regulation of metabolic process | cellular metabolic process | ATP metabolic process | regulation of cell death | negative regulation of cell death | nucleoside diphosphate phosphorylation | regulation of cellular component organization | response to other organism | negative regulation of cellular response to hypoxia | nucleoside monophosphate biosynthetic process | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | intracellular membrane-bounded organelle | catalytic complex | sarcomere | cell | A band | M band | myofibril | cytoplasm | intracellular organelle | contractile fiber | protein-containing complex | plasma membrane | vesicle | extracellular exosome | cytoplasmic region | phosphopyruvate hydratase complex | cell cortex region | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cell periphery | cytosol | cell surface | intracellular | membrane | supramolecular complex
