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QuickView for Pik3r1 (gene)


Gene Symbol:
PIK3R1 Homo sapiens Homo sapiens
Full name:
phosphoinositide-3-kinase regulatory subunit 1
Synonyms:
AGM7, GRB1, IMD36, p85, p85-ALPHA, phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha), phosphatidylinositol 3-kinase-associated p-85 alpha, phosphoinositide-3-kinase regulatory subunit alpha, phosphoinositide-3-kinase, regulatory subunit 1 (alpha), ptdIns-3-kinase regulatory subunit alpha
Genomic Location:
Chr 5: 67558218-67633405
Description:
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin...
Orthologs:
Mus musculus Rattus norvegicus C. elegans Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
GATTGGY_NFY_Q6_01 CACTGTG_MIR128A_MIR128B ATAAGCT_MIR21 RYTTCCTG_ETS2_B AREB6_02 HOXA4_Q2 AML_Q6 E4BP4_01 NFY_C CTATGCA_MIR153
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-103 Predicted Gene Targets for miR-128 Predicted Gene Targets for miR-129 Predicted Gene Targets for miR-15 Predicted Gene Targets for miR-153 Predicted Gene Targets for miR-185 Predicted Gene Targets for miR-20 Predicted Gene Targets for miR-21 Predicted Gene Targets for miR-218 Predicted Gene Targets for miR-30-3p
Cytogenetic Map:
chr 5
5q13.1





GO Molecular Function

protein phosphorylated amino acid binding | phosphatidylinositol 3-kinase binding | kinase binding | peptide binding | peptide hormone binding | kinase regulator activity | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | protein-containing complex binding | phosphotyrosine residue binding | insulin binding | transmembrane receptor protein tyrosine kinase adaptor activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | catalytic activity | ErbB-3 class receptor binding | signaling adaptor activity | protein binding, bridging | neurotrophin receptor binding | 1-phosphatidylinositol-3-kinase regulator activity | phosphatidylinositol 3-kinase regulator activity | neurotrophin TRKA receptor binding | phosphatidylinositol 3-kinase regulatory subunit binding | amide binding | phosphatidylinositol 3-kinase activity | protein heterodimerization activity | protein tyrosine kinase binding | molecular adaptor activity | hormone binding | phosphoprotein binding | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | protein binding | insulin receptor binding | protein phosphatase binding | transcription factor binding | 1-phosphatidylinositol-3-kinase activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | transferase activity | insulin-like growth factor receptor binding | enzyme regulator activity | kinase activity | phosphatase binding | insulin receptor substrate binding

GO Biological Process

positive regulation of immune response | positive regulation of endoplasmic reticulum unfolded protein response | regulation of supramolecular fiber organization | response to radiation | cell morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of intracellular protein transport | negative regulation of immune system process | response to endoplasmic reticulum stress | response to cytokine | cell motility | neuron projection morphogenesis | immune response-regulating signaling pathway | regulation of endoplasmic reticulum unfolded protein response | regulation of cellular localization | intracellular signal transduction | protein stabilization | regulation of localization | regulation of programmed cell death | phosphatidylinositol metabolic process | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | response to hormone | negative regulation of cellular process | positive regulation of lymphocyte activation | regulation of protein localization to membrane | regulation of protein import | cell differentiation | immune response-activating cell surface receptor signaling pathway | T cell receptor signaling pathway | negative regulation of cell-matrix adhesion | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | response to growth hormone | lymphocyte costimulation | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | glucose homeostasis | negative regulation of osteoclast differentiation | positive regulation of cell adhesion | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | phosphatidylinositol-3-phosphate biosynthetic process | B cell differentiation | phospholipid metabolic process | intracellular transport | positive regulation of cellular biosynthetic process | cellular process | Fc-gamma receptor signaling pathway involved in phagocytosis | lymphocyte differentiation | regulation of glucose import | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | extrinsic apoptotic signaling pathway | protein transport | neuron development | kinase regulator activity | immune system development | macromolecule localization | hemostasis | negative regulation of apoptotic process | axon guidance | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | cellular response to growth hormone stimulus | establishment of localization in cell | response to peptide hormone | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | interspecies interaction between organisms | intrinsic apoptotic signaling pathway | regulation of protein kinase B signaling | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | protein import into nucleus | epidermal growth factor receptor signaling pathway | cellular response to organonitrogen compound | insulin-like growth factor receptor signaling pathway | cellular component organization | cellular lipid metabolic process | positive regulation of tumor necrosis factor production | response to UV | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | transmembrane receptor protein tyrosine kinase adaptor activity | positive regulation of immune system process | negative regulation of cell adhesion | cellular response to light stimulus | response to stress | neuron projection guidance | intracellular protein transport | regulation of response to endoplasmic reticulum stress | positive regulation of cellular protein localization | positive regulation of RNA splicing | response to peptide | positive regulation of cell-cell adhesion | protein localization to nucleus | positive regulation of glucose import | programmed cell death | phosphatidylinositol-mediated signaling | positive regulation of cell activation | cellular localization | positive regulation of T cell activation | immune response-activating signal transduction | extrinsic apoptotic signaling pathway via death domain receptors | ERBB signaling pathway | regulation of protein transport | G-protein coupled receptor signaling pathway | positive regulation of RNA biosynthetic process | hemopoiesis | negative regulation of hemopoiesis | protein modification process | regulation of peptide transport | regulation of cell adhesion | cellular biosynthetic process | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | regulation of intracellular transport | molecular function regulator | ERBB2 signaling pathway | leukocyte migration | blood coagulation | regulation of nucleic acid-templated transcription | leukocyte differentiation | regulation of cellular response to stress | locomotion | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | signaling adaptor activity | response to light stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | cellular glucose homeostasis | cellular response to peptide hormone stimulus | phosphorus metabolic process | regulation of actin filament organization | cellular response to DNA damage stimulus | cellular response to insulin stimulus | positive regulation of protein kinase B signaling | regulation of catalytic activity | lipid metabolic process | regulation of actomyosin structure organization | regulation of phosphorylation | 1-phosphatidylinositol-3-kinase regulator activity | phosphatidylinositol 3-kinase regulator activity | positive regulation of glucose import in response to insulin stimulus | wound healing | Fc-gamma receptor signaling pathway | regulation of T cell activation | positive regulation of protein localization to plasma membrane | regulation of gene expression | platelet activation | axon development | organic substance transport | cellular response to stress | cellular response to peptide | positive regulation of intracellular protein transport | regulation of glucose import in response to insulin stimulus | organophosphate metabolic process | insulin receptor signaling pathway | positive regulation of cellular metabolic process | regulation of lymphocyte activation | cellular response to radiation | negative regulation of myeloid cell differentiation | phospholipid biosynthetic process | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | phosphatidylinositol 3-kinase activity | axonogenesis | protein localization to organelle | import into nucleus | Fc-epsilon receptor signaling pathway | positive regulation of cell migration | cellular response to cytokine stimulus | positive regulation of glucose transmembrane transport | B cell activation | positive regulation of protein localization to nucleus | biosynthetic process | negative regulation of cell-substrate adhesion | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | lipid biosynthetic process | inositol lipid-mediated signaling | protein phosphorylation | regulation of tumor necrosis factor production | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | cellular response to UV | positive regulation of cellular response to insulin stimulus | protein import | lipid phosphorylation | regulation of lipid kinase activity | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | positive regulation of signal transduction | lipid modification | homeostatic process | positive regulation of establishment of protein localization | regulation of locomotion | glycerolipid metabolic process | regulation of RNA metabolic process | positive regulation of transport | regulation of phospholipid metabolic process | viral process | coagulation | apoptotic signaling pathway | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | lymphocyte activation | regulation of nucleocytoplasmic transport | neuron differentiation | activation of immune response | protein metabolic process | regulation of establishment of protein localization | response to organic substance | regulation of protein import into nucleus | regulation of hemopoiesis | glycerophospholipid biosynthetic process | 1-phosphatidylinositol-3-kinase activity | regulation of kinase activity | response to wounding | import into cell | regulation of intracellular signal transduction | phosphatidylinositol 3-kinase signaling | establishment of protein localization to organelle | response to insulin | anatomical structure development | cell surface receptor signaling pathway | cell projection organization | metabolic process | regulation of RNA splicing | regulation of protein localization to plasma membrane | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of body fluid levels | negative regulation of programmed cell death | cellular protein localization | amide transport | chemical homeostasis | endocytosis | neuron projection development | organic substance metabolic process | nuclear transport | cell death | regulation of glucose transmembrane transport | animal organ development | regulation of insulin receptor signaling pathway | regulation of cell activation | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | phosphatidylinositol biosynthetic process | antigen receptor-mediated signaling pathway | establishment of protein localization | positive regulation of cytokine production | positive regulation of intracellular transport | cell activation | positive regulation of protein transport | regulation of stress fiber assembly | regulation of osteoclast differentiation | T cell costimulation | regulation of cell communication | signaling | regulation of transcription, DNA-templated | cell development | growth hormone receptor signaling pathway | protein localization | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | phosphatidylinositol phosphorylation | anatomical structure morphogenesis | cellular macromolecule localization | regulation of actin filament bundle assembly | positive regulation of protein import into nucleus | nucleocytoplasmic transport | regulation of developmental process | glycerophospholipid metabolic process | kinase activity | developmental process | positive regulation of protein import | Fc receptor signaling pathway | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | Fc receptor mediated stimulatory signaling pathway | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of actin filament-based process | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | carbohydrate homeostasis | chemotaxis | positive regulation of nucleocytoplasmic transport | phagocytosis | positive regulation of leukocyte cell-cell adhesion | negative regulation of myeloid leukocyte differentiation | negative regulation of cell differentiation | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of cell-matrix adhesion | macromolecule metabolic process | positive regulation of response to endoplasmic reticulum stress | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

perinuclear endoplasmic reticulum membrane | intracellular membrane-bounded organelle | catalytic complex | phosphatidylinositol 3-kinase complex | extrinsic component of membrane | cell | cis-Golgi network | cytoplasm | intracellular organelle | endoplasmic reticulum | cell-cell junction | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | plasma membrane | transferase complex | perinuclear region of cytoplasm | phosphatidylinositol 3-kinase complex, class IA | membrane-bounded organelle | nucleus | organelle | cell periphery | perinuclear endoplasmic reticulum | cytosol | intracellular | cell junction | membrane