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QuickView for Pipobroman (compound)


PubChem
Name: Pipobroman
PubChem Compound ID: 4842
Description: An antineoplastic agent that acts by alkylation.
Molecular formula: C10H16Br2N2O2
Molecular weight: 356.054 g/mol
Synonyms:
5-23-01-00046 (Beilstein Handbook Reference); CCRIS 2753; AIDS124365; Pipobroman [USAN:INN]; Spectrum2_000912; KBio1_000799; Amedel; N,N'-Bis(3-bromopropionyl)piperazine; Vercyte; Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-.
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DrugBank
Identification
Name: Pipobroman
Name (isomeric): DB00236
Drug Type: small molecule
Description: An antineoplastic agent that acts by alkylation.
Brand: Amedel, Vercyte
Category: Antineoplastic Agents, Antineoplastic Agents, Alkylating
CAS number: 54-91-1
Pharmacology
Indication: For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
Pharmacology: Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
Mechanism of Action: The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.
Absorption: Well absorbed from the GI tract.
Toxicity: Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
BisoprololAntagonism
LabetalolAntagonism
PenbutololAntagonism
BevantololAntagonism
SotalolAntagonism
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Targets