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QuickView for Pipobroman (compound)
PubChem
| Name: | Pipobroman |
|---|---|
| PubChem Compound ID: | 4842 |
| Description: | An antineoplastic agent that acts by alkylation. |
| Molecular formula: | C10H16Br2N2O2 |
| Molecular weight: | 356.054 g/mol |
| Synonyms: |
5-23-01-00046 (Beilstein Handbook Reference); CCRIS 2753; AIDS124365; Pipobroman [USAN:INN]; Spectrum2_000912; KBio1_000799; Amedel; N,N'-Bis(3-bromopropionyl)piperazine; Vercyte; Piperazine, 1,4-bis(3-bromo-1-oxopropyl)-.
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DrugBank
Identification
| Name: | Pipobroman |
|---|---|
| Name (isomeric): | DB00236 |
| Drug Type: | small molecule |
| Description: | An antineoplastic agent that acts by alkylation. |
| Brand: | Amedel, Vercyte |
| Category: | Antineoplastic Agents, Antineoplastic Agents, Alkylating |
| CAS number: | 54-91-1 |
Pharmacology
| Indication: | For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia. |
|---|---|
| Pharmacology: | Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia. |
| Mechanism of Action: | The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death. |
| Absorption: | Well absorbed from the GI tract. |
| Toxicity: | Symptoms of overdose include hematologic toxicity, especially with chronic overdosage. |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
