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QuickView for Pipotiazine (compound)

Name: pipothiazine
PubChem Compound ID: 62867
Molecular formula: C24H33N3O3S2
Molecular weight: 475.669 g/mol
Pipothiazine; Pipotiazinum [INN-Latin]; Pipotiazine; 39860-99-6; EINECS 254-659-6; Pipotiazina [INN-Spanish]; 10H-Phenothiazine-2-sulfonamide,10-(3-(4-(2-hydroxyethyl)-1-piperidinyl)propyl)-N,N-dimethyl-
Name: pipothiazine
Name (isomeric): DB01621
Drug Type: small molecule
Pipothiazine; Pipotiazina [inn-spanish]; Pipotiazinum [inn-latin]
Brand: Piportil Depot, Piportil L4
Category: Phenothiazines, Antipsychotic Agents
CAS number: 39860-99-6
Indication: For the maintenance treatment of chronic non-agitated schizophrenic patients.
Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It reduces activity ...
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Mechanism of Action:
Pipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuat...
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Toxicity: Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Affected organisms: Humans and other mammals
Food interaction:
Take with food to decrease irritation
Avoid alcohol
Drug interaction:
VoriconazoleVoriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of pipotiazine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of pipotiazine if voriconazole is initiated, discontinued or dose changed.
TriprolidineThe antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Pipotiazine. Monitor for symptoms of ventricular arrhythmias.
DonepezilPossible antagonism of action
TelithromycinTelithromycin may reduce clearance of Pipotiazine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Pipotiazine if Telithromycin is initiated, discontinued or dose changed.
TerbinafineTerbinafine may reduce the metabolism and clearance of Pipotiazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Pipotiazine if Terbinafine is initiated, discontinued or dose changed.
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