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QuickView for Pirbuterol (compound)

Name: pirbuterol
PubChem Compound ID: 171674
Molecular formula: C14H24N2O5
Molecular weight: 300.351 g/mol
2,6-Pyridinedimethanol, alpha(sup 6)-(((1,1-dimethylethyl)amino)methyl)-3-hydroxy-, monoacetate (salt); 38677-81-5; Pirbuterol acetate (USAN); Pirbuterol acetate [USAN]; 65652-44-0; Maxair (TN); Maxair; EINECS 265-862-4; D00686; alpha(sup 6)-((tert-Butylamino)methyl)-3-hydroxy-2,6-pyridinedimethanol monoacetate (salt).
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Name: pirbuterol
Name (isomeric): DB01291
Drug Type: small molecule
Pirbuterol hydrochloride; Pirbuterolum [inn-latin]
Brand: Maxair
Category: Adrenergic beta-Agonists, Cardiotonic Agents, Bronchodilator Agents
CAS number: 38677-81-5
Indication: For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma.
Pirbuterol is a beta-2 adrenergic bronchodilator. In vitro studies and in vivo pharmacologic studies have demonstrated that pirbuterol has a preferential effect on beta-2 adrenergic receptors compared with isoproterenol. While it is recognized that beta-2 adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicate t...
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Mechanism of Action:
The pharmacologic effects of beta adrenergic agonist drugs, including pirbuterol, are at least in proof attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (AlP) to cyclic-3† ,5†-adenosine monophosphate (c-AMP). Increased c-AMP...
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Half Life: The plasma half-life measured after oral administration is about two hours.
Toxicity: As with all sympathomimetic aerosol medication, cardiac arrest and even death may be associated with abuse of pirbuterol.
Affected organisms: Humans and other mammals
Drug interaction:
PhenelzineIncreased arterial pressure
AmoxapineThe tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of pirbuterol.
ReserpineIncreased arterial pressure
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