QuickView for Pirh2 (gene)

Gene Symbol:

RCHY1 Homo sapiens

Full name:

ring finger and CHY zinc finger domain containing 1

Synonyms:

ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363, RING finger and CHY zinc finger domain-containing protein 1, CH-rich interacting match with PLAG1, E3 ubiquitin-protein ligase Pirh2, RING finger protein 199, RING-type E3 ubiquitin transferase RCHY1, androgen-receptor N-terminal-interacting protein, p53-induced protein with a RING-H2 domain, ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase, zinc finger protein 363, zinc finger, CHY-type

Genomic Location:

Chr 4: 76623371-76658652

Description:

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encodi...

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The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CART1_01

Cytogenetic Map:

4q21.1

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