QuickView for Pla2g6 (gene)

Gene Symbol:

PLA2G6 Homo sapiens

Full name:

phospholipase A2 group VI

Synonyms:

CaI-PLA2, GVI, INAD1, IPLA2-VIA, NBIA2, NBIA2A, NBIA2B, PARK14, PLA2, PNPLA9, iPLA2, iPLA2beta, 85/88 kDa calcium-independent phospholipase A2, 85 kDa calcium-independent phospholipase A2, GVI PLA2, iPLA2-beta, intracellular membrane-associated calcium-independent phospholipase A2 beta, neurodegeneration with brain iron accumulation 2, patatin-like phospholipase domain-containing protein 9, phospholipase A2, group VI (cytosolic, calcium-independent)

Genomic Location:

Chr 22: 36837448-36907707

Description:

The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells....

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The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TTANTCA_UNKNOWN ,  CACGTG_MYC_Q2 ,  MYB_Q5_01 ,  MYAATNNNNNNNGGC_UNKNOWN ,  CACCCBINDINGFACTOR_Q6 ,  CAGGTG_E12_Q6 ,  SCGGAAGY_ELK1_02

Cytogenetic Map:

22q13.1

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