QuickView for Pnc1 (gene)
- Gene Symbol:
- PNC1
Saccharomyces cerevisiae - Full name:
- Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span
- Synonyms:
- Pnc1, PNC1, YGL037C
- Genomic Location:
- Chr VII: 427303-427953
- Orthologs:
- D. melanogaster , Schizosaccharomyces pombe
- External Links:
- Entrez Gene
GO Molecular Function
cation binding | hydrolase activity | nicotinamidase activity | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | ion binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding
GO Biological Process
chromatin silencing at telomere | negative regulation of cellular process | negative regulation of RNA biosynthetic process | negative regulation of DNA metabolic process | cellular process | regulation of gene expression, epigenetic | negative regulation of DNA biosynthetic process | chromatin organization | nucleotide metabolic process | negative regulation of nucleic acid-templated transcription | replicative cell aging | negative regulation of cellular metabolic process | regulation of cellular process | gene silencing | regulation of metabolic process | nicotinate nucleotide salvage | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cofactor metabolic process | cellular biosynthetic process | nucleotide biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | coenzyme biosynthetic process | phosphorus metabolic process | regulation of gene expression | organophosphate metabolic process | negative regulation of gene expression, epigenetic | cofactor biosynthetic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | nicotinate nucleotide biosynthetic process | nucleobase-containing small molecule metabolic process | negative regulation of DNA amplification | biosynthetic process | aromatic compound biosynthetic process | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of RNA metabolic process | cell aging | pyridine nucleotide biosynthetic process | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | chromatin silencing at rDNA | regulation of transcription, DNA-templated | developmental process | organelle organization | regulation of DNA biosynthetic process | heterocycle metabolic process | chromosome organization | chromatin silencing | cellular metabolic process | aging
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | peroxisome | cell | cytoplasm | intracellular organelle | chromosome, telomeric region | membrane-bounded organelle | nucleus | organelle | intracellular
