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QuickView for PolD (gene)


Gene Symbol:
POLD1 Homo sapiens Homo sapiens
Full name:
DNA polymerase delta 1, catalytic subunit
Synonyms:
CDC2, CRCS10, MDPL, POLD, DNA polymerase delta catalytic subunit, CDC2 homolog, DNA polymerase subunit delta p125, polymerase (DNA directed), delta 1, catalytic subunit 125kDa, polymerase (DNA) delta 1, catalytic subunit
Genomic Location:
Chr 19: 55579405-55613083
Description:
This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chr...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Bos taurus Pan troglodytes Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 19
19q13.33





GO Molecular Function

nuclease activity | cofactor binding | cation binding | DNA-directed DNA polymerase activity | nucleic acid binding | nucleotide binding | hydrolase activity | DNA polymerase activity | nucleotidyltransferase activity | catalytic activity | chromatin binding | exodeoxyribonuclease activity | iron-sulfur cluster binding | deoxyribonuclease activity | DNA binding | hydrolase activity, acting on ester bonds | damaged DNA binding | ion binding | organic cyclic compound binding | protein binding | transferase activity, transferring phosphorus-containing groups | 3'-5' exonuclease activity | transferase activity | 4 iron, 4 sulfur cluster binding | exonuclease activity | metal ion binding | 3'-5'-exodeoxyribonuclease activity | heterocyclic compound binding | small molecule binding

GO Biological Process

response to radiation | telomere maintenance | detection of stimulus | nuclease activity | translesion synthesis | cellular process | DNA-dependent DNA replication maintenance of fidelity | cellular homeostasis | cell cycle DNA replication | DNA-directed DNA polymerase activity | anion homeostasis | postreplication repair | anatomical structure homeostasis | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | response to UV | response to stimulus | cellular response to light stimulus | response to stress | cellular nitrogen compound biosynthetic process | DNA polymerase activity | cellular nitrogen compound metabolic process | telomere organization | nucleic acid phosphodiester bond hydrolysis | cellular biosynthetic process | DNA repair | response to light stimulus | nitrogen compound metabolic process | DNA replication proofreading | cellular response to DNA damage stimulus | nucleotide-excision repair, DNA incision, 5'-to lesion | DNA biosynthetic process | exodeoxyribonuclease activity | cellular response to stress | cell cycle | cellular response to radiation | deoxyribonuclease activity | telomere maintenance via semi-conservative replication | biosynthetic process | aromatic compound biosynthetic process | cellular response to UV | base-excision repair | homeostatic process | nucleotide-excision repair, DNA gap filling | DNA metabolic process | fatty acid homeostasis | nucleotide-excision repair, DNA incision | DNA damage response, detection of DNA damage | metabolic process | nucleotide-excision repair | 3'-5' exonuclease activity | chemical homeostasis | nucleobase-containing compound metabolic process | organic substance metabolic process | base-excision repair, gap-filling | ion homeostasis | transcription-coupled nucleotide-excision repair | cellular macromolecule biosynthetic process | nuclear DNA replication | organelle organization | exonuclease activity | DNA synthesis involved in DNA repair | heterocycle metabolic process | 3'-5'-exodeoxyribonuclease activity | chromosome organization | cellular metabolic process | DNA replication | lipid homeostasis | macromolecule metabolic process

GO Cellular Component

nuclear replisome | chromosome | intracellular membrane-bounded organelle | catalytic complex | nuclear replication fork | DNA repair complex | cell | nuclear lumen | replication fork | cytoplasm | intracellular organelle | inclusion body | protein-containing complex | nucleotide-excision repair complex | protein-DNA complex | nucleoplasm | nuclear chromosome | transferase complex | chromosome, telomeric region | membrane-bounded organelle | aggresome | nucleus | organelle | replisome | membrane-enclosed lumen | delta DNA polymerase complex | cytosol | nuclear chromosome, telomeric region | intracellular | membrane