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QuickView for Polystyrene sulfonate (compound)
DrugBank
Identification
| Name: | polystyrene sulfonate |
|---|---|
| Name (isomeric): | DB01344 |
| Drug Type: | small molecule |
| Synonyms: |
Sodium polystyrene sulfonic acid; SPS; Polystyrene sulfonic acid; Sodium polystyrene sulfonate
|
| Brand: | Kayexalate, Kionex |
| CAS number: | 28210-41-5 |
Pharmacology
| Indication: | Used to treat abnormally high potassium levels. |
|---|---|
| Pharmacology: | Polystyrene sulfonate affects the exchange of sodium and potassium in the body. Polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. It is a potassium-binding ion-exchange resin that can be administered orally (25 grams in 20% sorbitol) or rectally (50 grams in 20% sorbitol). |
| Mechanism of Action: | Polystyrene sulfonate, which is not absorbed, binds excess potassium, carrying it out of the body. The indigestible potassium polystryene sulfonate complex is excreted with the faeces, preventing the absorption of potassium into the blood stream. Hence, the serum potassium level decreases. |
| Absorption: | Not absorbed following oral administration. |
| Biotransformation: | none |
| Route of elimination: | Feces. |
| Half Life: | none |
| Toxicity: | Overdose symptoms may include confusion, irritability, trouble thinking or concentrating, muscle weakness, or trouble breathing. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
