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QuickView for Potassium Chloride (compound)


PubChem
Name: Potassium Chloride
PubChem Compound ID: 4873
Description: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Molecular formula: ClK
Molecular weight: 74.551 g/mol
Synonyms:
Chloropotassuril; NSC77368; Enseal; Kaon-Cl; potassium chloride; component of K-Predne-Dome; Kalitabs; Potassium chloride (KCl); 7447-40-7; Slow-K.
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DrugBank
Identification
Name: Potassium Chloride
Name (isomeric): DB00761
Drug Type: small molecule
Description: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.
Synonyms:
Potassium thallium chloride (KTlCl); Tripotassium trichloride; Chloride of potash; ClK; Monopotassium chloride; Dipotassium dichloride; Hydrochloric acid potassium salt (1:1); Potassium monochloride; Chlorid draselny [Czech]
Brand: Klor-Lyte, Potassium Chloride 10meq in Plastic Container, Kaleorid, Kadalex, Kalium-duriles, K-SR, Kalium-Durettes, Miopotasio, Sando-K, Sal digestnum sylvii, Keylyte, Durekal, Durules, Addi-K, K-Lor, Potassium Chloride BP, Peter-kal, Kaon-Cl, Clor-K-Zaf, Diffu-K, Emplets potassium chloride, K-Lyte/Cl, Lento-K, Klorvess, Kayback, Celeka, K-Care, KM potassium chloride, Micro-K, Ten-K, Potassium muriate, Potasion, Kalipoz, Kloren, K. tab, Micro-Kalium Retard, Kalipor, Kalium Duriles, Kalium Durules, Kalium-R, Leo K, Trona potassium chloride, Steropotassium, K-Lyte Cl, Kay Ciel, Slow-K, Kalcorid, Enpott, K-Contin, Colyte, Lento-kalium, Kalium SR, Ultra K Chlor, KCl, Kalitrans Retard, Enseal, Kato, Chloropotassuril, Kay-cee-l, K-Norm, KSR, Chlorvescent, Potavescent, K-Sol, Super K, Repone K, K-dur, Selora, Repone-K, Kay-EM, Micro-K LS, Infalyte, Klor-Con M20, Rum-K, Rekawan, Kaliumchlorid, KCL Retard, Micro-K Extentcaps, Kalinor-Retard P, Span-K, Rekawan Retard, Klotrix, Pfiklor, K-Lease, Kalinorm, Acronitol, Chloropotassuril diffu-K, Muriate of potash, Kaliolite, Kalilente, Kaon-ci, Klor-Con, K-Tab, KCl-retard Zyma, Kaskay, Kaon CL, Kaliduron, Ultra-K-Chlor, Trona muriate of potash, Natural sylvite, Apo-K, Durules-K, Kaleorod, Cena-K, K Tab, K-lyte/C1, Kalium Retard, Kaon Ultra, Kolyum, Kalium S.R., Nu-K, Potasol, K-Grad, Duffi-K, K-Predne-dome, Kay-Ciel, Plus Kalium Retard, Kalitabs, Neobakasal, Kaliglutol, Kaochlor, Kelp salt, Leo-K
Brand name mixture:
multi vitamins and minerals - senior(beta-carotene (provitamin a) + biotin + calcium (calcium phosphate (dibasic), calcium carbonate) + chlorine (potassium chloride) + chromium (chromic chloride) + copper (cupric oxide) + d-pantothenic acid (calcium d-pantothenate) + folic acid + iodine (potassium iodide) + iron (ferrous fumarate) + magnesium (m...
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CAS number: 7447-40-7
Pharmacology
Indication: For use as an electrolyte replenisher and in the treatment of hypokalemia.
Pharmacology:
The potassium ion is in the principle intracellular cation of most body tissues. Potassium ions participate in a number of essential physiological processes including the maintenance of intracellular tonicity, the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle, and the maintenance of normal renal function. Th...
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Mechanism of Action: Supplemental potassium in the form of high potassium food or potassium chloride may be able to restore normal potassium levels.
Absorption: Potassium is a normal dietary constituent and under steady-state conditions the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine.
Route of elimination: Potassium is a normal dietary constituent and, under steady-state conditions, the amount of potassium absorbed from the gastrointestinal tract is equal to the amount excreted in the urine. Potassium depletion will occur whenever the rate of potassium loss through renal excretion and/or loss from the gastrointestinal tract exceeds the rate of potassium intake.
Toxicity: The administration of oral potassium salts to persons with normal excretory mechanisms for potassium rarely causes serious hyperkalemia. However, if excretory mechanisms are impaired, of if potassium is administered too rapidly intravenously, potentially fatal hyperkalemia can result. It is important to recognize that hyperkalemia is usually asymptomatic and may be manifested only by an increased serum potassium concentration (6.5-8.0 mEq/L) and characteristic electrocardiographic changes (peaking of T-waves, loss of P-wave, depression of S-T segment, and prolongation of the QT interval). Late manifestations include muscle paralysis and cardiovascular collapse from cardiac arrest (9-12 mEq/L).
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with a full glass of water Take after a full meal.
Drug interaction:
TrospiumThe ulcerative effects of solid oral dosage forms of KCl may be enhanced by Trospium, an anticholinergic. Anticholinergics slow gastric emptying, increasing the contact time between the gastrointestinal mucosa and KCl. Prolonged exposure to KCl increases the risk of gastric and intestinal irritation and ulceration. Solid oral dosage forms of KCl should be avoided; alternatives include liquid or effervescent potassium preparations.
TrihexyphenidylThe ulcerative effects of solid oral dosage forms of KCl may be enhanced by Trihexyphenidyl, an anticholinergic. Anticholinergics slow gastric emptying, increasing the contact time between the gastrointestinal mucosa and KCl. Prolonged exposure to KCl increases the risk of gastric and intestinal irritation and ulceration. Solid oral dosage forms of KCl should be avoided; alternatives include liquid or effervescent potassium preparations.
TrandolaprilThe potassium salt may increase the hyperkalemic effect of Trandolapril.
TelmisartanPotassium Chloride may increase the hyperkalemic effect of Telmisartan. Monitor serum potassium levels during concomitant use.
TiotropiumThe ulcerative effects of solid oral dosage forms of KCl may be enhanced by Tiotropium, an anticholinergic. Anticholinergics slow gastric emptying, increasing the contact time between the gastrointestinal mucosa and KCl. Prolonged exposure to KCl increases the risk of gastric and intestinal irritation and ulceration. Solid oral dosage forms of KCl should be avoided; alternatives include liquid or effervescent potassium preparations.
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