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QuickView for Pou5f1 (gene)


Gene Symbol:
POU5F1 Homo sapiens Homo sapiens
Full name:
POU class 5 homeobox 1
Synonyms:
OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4, POU domain, class 5, transcription factor 1, POU class 5 homeobox 1 transcript variant OCT4B1, POU class 5 homeobox 1 transcript variant OCT4B2, POU class 5 homeobox 1 transcript variant OCT4B3, POU class 5 homeobox 1 transcript variant OCT4B4, POU class 5 homeobox 1 transcript variant OCT4B5, POU class 5 homeobox 1 transcript variant OCT4B6, POU classV homeobox 1 variant 2, POU domain transcription factor OCT4, POU-type homeodomain-containing DNA-binding protein, octamer-binding protein 3, octamer-binding protein 4, octamer-binding transcription factor 3
Genomic Location:
Chr 6: 31240093-31246430
Description:
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor fo...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 6
6p21.33





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | enzyme binding | nucleic acid binding | ubiquitin-like protein ligase binding | miRNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | ubiquitin protein ligase binding | heterocyclic compound binding | RNA binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | somatic stem cell population maintenance | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | negative regulation of gene silencing by RNA | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | regulation of cell division | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | regulation of gene silencing | cellular nitrogen compound metabolic process | endodermal cell fate commitment | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | mRNA metabolic process | cellular biosynthetic process | embryo development | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | multicellular organism development | mRNA transcription by RNA polymerase II | regulation of gene expression | negative regulation of gene silencing by miRNA | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | endoderm formation | biosynthetic process | aromatic compound biosynthetic process | endodermal cell fate specification | chordate embryonic development | regulation of cellular metabolic process | regulation of asymmetric cell division | mRNA transcription | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | embryonic morphogenesis | negative regulation of gene silencing | DNA-binding transcription factor activity | response to wounding | anatomical structure development | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of gene silencing by RNA | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | transcription, DNA-templated | blastocyst development | anatomical structure formation involved in morphogenesis | regulation of transcription, DNA-templated | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | developmental process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | in utero embryonic development | positive regulation of metabolic process | gastrulation | cellular metabolic process | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular