QuickView for Pparg (gene)
- Gene Symbol:
- PPARG
Homo sapiens - Full name:
- peroxisome proliferator activated receptor gamma
- Synonyms:
- CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator-activated receptor gamma, PPAR-gamma, nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated nuclear receptor gamma variant 1
- Genomic Location:
- Chr 3: 12304349-12450855
- Description:
-
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PP...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3p25.2
GO Molecular Function
sequence-specific DNA binding | fatty acid binding | protein self-association | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | peptide binding | long-chain fatty acid binding | prostaglandin receptor activity | retinoic acid receptor binding | nuclear receptor activity | cation binding | repressing transcription factor binding | hormone receptor binding | DBD domain binding | transcription factor activity, direct ligand regulated sequence-specific DNA binding | transmembrane signaling receptor activity | proximal promoter sequence-specific DNA binding | carboxylic acid binding | enzyme binding | nucleic acid binding | lipid binding | G-protein coupled receptor activity | estrogen receptor binding | signaling receptor binding | arachidonic acid binding | alpha-actinin binding | LBD domain binding | steroid hormone receptor activity | chromatin binding | protein domain specific binding | cytoskeletal protein binding | anion binding | RNA polymerase II repressing transcription factor binding | RNA polymerase II regulatory region DNA binding | E-box binding | amide binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | identical protein binding | icosatetraenoic acid binding | nuclear hormone receptor binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | retinoid X receptor binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | protein phosphatase binding | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | protein dimerization activity | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | steroid hormone receptor binding | drug binding | phosphatase binding | transcription coregulator activity | actinin binding | organic acid binding | metal ion binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | cellular response to increased oxygen levels | DNA-templated transcription, initiation | long-chain fatty acid transport | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to nutrient levels | negative regulation of immune system process | negative regulation of sequestering of triglyceride | macrophage derived foam cell differentiation | positive regulation of cellular component organization | regulation of neurogenesis | developmental process involved in reproduction | regulation of cholesterol transport | positive regulation of apoptotic process | regulation of cell development | regulation of localization | negative regulation of collagen biosynthetic process | positive regulation of DNA-binding transcription factor activity | lipid transport | regulation of programmed cell death | response to immobilization stress | establishment of localization | regulation of immune system process | response to hormone | myeloid cell differentiation | cellular response to hyperoxia | negative regulation of vascular endothelial cell proliferation | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of fatty acid oxidation | positive regulation of developmental process | pri-miRNA transcription by RNA polymerase II | negative regulation of RNA biosynthetic process | cell differentiation | defense response | nervous system development | cellular response to extracellular stimulus | response to drug | regulation of phagocytosis, engulfment | neurogenesis | glucose homeostasis | negative regulation of gene silencing by RNA | generation of neurons | peroxisome proliferator activated receptor signaling pathway | negative regulation of DNA metabolic process | regulation of response to interferon-gamma | regulation of lipid transport | hormone-mediated signaling pathway | prostaglandin receptor activity | positive regulation of cellular biosynthetic process | cellular process | negative regulation of DNA biosynthetic process | negative regulation of inflammatory response | nuclear receptor activity | monocarboxylic acid transport | regulation of cell motility | localization | cell maturation | protein transport | negative regulation of signaling | reproductive system development | anion transport | immune system development | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | negative regulation of innate immune response | macromolecule localization | regulation of response to cytokine stimulus | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | negative regulation of cholesterol storage | positive regulation of muscle cell apoptotic process | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | cellular response to low-density lipoprotein particle stimulus | response to prostaglandin | negative regulation of receptor biosynthetic process | cellular response to retinoic acid | regeneration | negative regulation of cell motility | negative regulation of acute inflammatory response | regulation of angiogenesis | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | cellular response to prostaglandin stimulus | regulation of interferon-gamma-mediated signaling pathway | low-density lipoprotein receptor particle metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | cellular lipid metabolic process | G-protein coupled receptor activity | regulation of vasculature development | response to stimulus | monocarboxylic acid metabolic process | regulation of macrophage derived foam cell differentiation | positive regulation of protein metabolic process | positive regulation of peptidase activity | positive regulation of smooth muscle cell apoptotic process | response to cold | response to stress | cellular response to vitamin | cellular nitrogen compound biosynthetic process | positive regulation of phagocytosis, engulfment | regulation of cell proliferation | negative regulation of angiogenesis | response to peptide | positive regulation of cysteine-type endopeptidase activity | response to starvation | reproduction | response to alcohol | response to temperature stimulus | rhythmic process | positive regulation of proteolysis | regulation of gene silencing | cellular nitrogen compound metabolic process | lipoprotein transport | regulation of DNA binding | positive regulation of gliogenesis | cellular response to organic cyclic compound | regulation of phagocytosis | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | steroid hormone receptor activity | steroid hormone mediated signaling pathway | cellular biosynthetic process | regulation of lipid storage | regulation of oligodendrocyte differentiation | receptor biosynthetic process | regulation of nucleic acid-templated transcription | leukocyte differentiation | response to nitrogen compound | cellular response to hormone stimulus | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of growth | multicellular organism development | negative regulation of catalytic activity | cellular response to peptide hormone stimulus | regulation of peptidase activity | response to purine-containing compound | regulation of collagen biosynthetic process | response to fatty acid | response to vitamin E | cellular response to insulin stimulus | regulation of catalytic activity | lipid metabolic process | regulation of acute inflammatory response | monocyte differentiation | cellular response to prostaglandin E stimulus | regulation of cholesterol transporter activity | regulation of gene expression | fatty acid transport | response to prostaglandin E | negative regulation of gene silencing by miRNA | organic substance transport | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | regulation of blood pressure | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | regulation of telomerase activity | negative regulation of lipid storage | negative regulation of smooth muscle cell proliferation | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | peptide transport | response to metformin | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | regulation of smooth muscle cell apoptotic process | fat cell differentiation | organic acid transport | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of hydrolase activity | regulation of fatty acid metabolic process | positive regulation of cell differentiation | regulation of endothelial cell migration | negative regulation of epithelial cell migration | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of immune response | organic anion transport | response to hyperoxia | response to vitamin A | positive regulation of endopeptidase activity | response to xenobiotic stimulus | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of blood vessel endothelial cell migration | response to estrogen | regulation of muscle cell apoptotic process | low-density lipoprotein particle receptor biosynthetic process | cell communication | regulation of cellular metabolic process | regulation of collagen metabolic process | regulation of protein metabolic process | heart development | lipid modification | homeostatic process | regulation of cytokine-mediated signaling pathway | regulation of locomotion | regulation of sequestering of triglyceride | transcription coactivator activity | regulation of RNA metabolic process | negative regulation of vascular smooth muscle cell proliferation | positive regulation of transport | response to retinoic acid | negative regulation of cell growth | cellular response to fatty acid | cellular response to lipoprotein particle stimulus | carboxylic acid metabolic process | positive regulation of molecular function | negative regulation of gene silencing | negative regulation of interferon-gamma-mediated signaling pathway | negative regulation of pancreatic stellate cell proliferation | negative regulation of epithelial cell proliferation | protein metabolic process | cellular response to nutrient | regulation of fibroblast proliferation | DNA-binding transcription factor activity | regulation of growth | cellular response to vitamin E | response to organic substance | regulation of innate immune response | response to mechanical stimulus | positive regulation of fatty acid metabolic process | regulation of DNA-binding transcription factor activity | response to insulin | anatomical structure development | positive regulation of neurogenesis | negative regulation of response to cytokine stimulus | metabolic process | lipid localization | positive regulation of cell development | cell fate commitment | regulation of receptor biosynthetic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | developmental maturation | oxidation-reduction process | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | positive regulation of glial cell differentiation | amide transport | regulation of vesicle-mediated transport | negative regulation of endothelial cell proliferation | chemical homeostasis | positive regulation of cell death | regulation of gene silencing by RNA | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | response to caffeine | organic substance metabolic process | response to vitamin | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | regulation of endothelial cell proliferation | gene expression | negative regulation of cellular component movement | positive regulation of programmed cell death | positive regulation of phagocytosis | regulation of fatty acid oxidation | response to alkaloid | cellular response to steroid hormone stimulus | positive regulation of binding | fatty acid metabolic process | establishment of protein localization | transcription initiation from RNA polymerase II promoter | regulation of transcription involved in cell fate commitment | transcription, DNA-templated | lipid oxidation | intracellular receptor signaling pathway | regulation of epithelial cell migration | regulation of glial cell differentiation | negative regulation of macrophage derived foam cell differentiation | foam cell differentiation | regulation of cell communication | regulation of blood vessel endothelial cell migration | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | positive regulation of DNA binding | regulation of endocytosis | protein localization | regulation of epithelial cell proliferation | organic acid metabolic process | negative regulation of fibroblast proliferation | carboxylic acid transport | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of fat cell differentiation | regulation of circadian rhythm | reproductive structure development | regulation of cellular ketone metabolic process | regulation of nervous system development | regulation of developmental process | developmental process | regulation of DNA biosynthetic process | regulation of cell growth | white fat cell differentiation | positive regulation of oligodendrocyte differentiation | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | innate immune response | negative regulation of vasculature development | receptor metabolic process | positive regulation of nucleic acid-templated transcription | negative regulation of endothelial cell migration | response to organonitrogen compound | transcription coregulator activity | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | negative regulation of cytokine-mediated signaling pathway | positive regulation of vascular associated smooth muscle cell apoptotic process | heterocycle metabolic process | fatty acid oxidation | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | ion transport | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | placenta development | cellular response to organic substance | regulation of cell death | regulation of smooth muscle cell proliferation | response to steroid hormone | circulatory system development | regulation of inflammatory response | carbohydrate homeostasis | negative regulation of locomotion | positive regulation of endocytosis | negative regulation of telomerase activity | lipid homeostasis | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | regulation of signaling | animal organ regeneration | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
