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QuickView for Ppia (gene)


Gene Symbol:
PPIA Homo sapiens Homo sapiens
Full name:
peptidylprolyl isomerase A
Synonyms:
CYPA, CYPH, HEL-S-69p, peptidyl-prolyl cis-trans isomerase A, PPIase A, T cell cyclophilin, cyclosporin A-binding protein, epididymis secretory sperm binding protein Li 69p, peptidylprolyl isomerase A (cyclophilin A), rotamase A
Genomic Location:
Chr 7: 44802766-44809241
Description:
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Pan troglodytes Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 7
7p13





GO Molecular Function

peptide binding | cyclosporin A binding | isomerase activity | nucleic acid binding | unfolded protein binding | catalytic activity | amide binding | peptidyl-prolyl cis-trans isomerase activity | organic cyclic compound binding | protein binding | virion binding | drug binding | heterocyclic compound binding | RNA binding

GO Biological Process

exocytosis | response to cytokine | cell motility | neutrophil activation | regulation of localization | viral release from host cell | peptidyl-amino acid modification | establishment of localization | membrane fusion | positive regulation of protein secretion | membrane organization | positive regulation of viral life cycle | cellular process | secretion | leukocyte degranulation | localization | peptidyl-proline modification | interspecies interaction between organisms | lipid droplet organization | regulation of cellular process | leukocyte activation | positive regulation of viral genome replication | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | entry into host cell | viral life cycle | regulation of peptide secretion | response to stimulus | neutrophil degranulation | leukocyte activation involved in immune response | cellular nitrogen compound biosynthetic process | secretion by cell | cellular nitrogen compound metabolic process | regulation of protein transport | protein modification process | regulation of peptide transport | cellular biosynthetic process | response to interleukin-12 | interleukin-12-mediated signaling pathway | macromolecule modification | leukocyte migration | positive regulation of peptide secretion | locomotion | nitrogen compound metabolic process | positive regulation of viral process | cell migration | leukocyte mediated immunity | DNA biosynthetic process | viral entry into host cell | positive regulation of secretion | RNA-dependent DNA biosynthetic process | cytokine-mediated signaling pathway | vesicle-mediated transport | cellular response to cytokine stimulus | biosynthetic process | establishment of viral latency | aromatic compound biosynthetic process | peptidyl-prolyl cis-trans isomerase activity | regulated exocytosis | cell communication | multi-organism membrane organization | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | positive regulation of establishment of protein localization | positive regulation of transport | viral process | regulation of viral process | protein metabolic process | regulation of establishment of protein localization | establishment of integrated proviral latency | response to organic substance | DNA metabolic process | cell surface receptor signaling pathway | metabolic process | virion assembly | regulation of secretion | immune response | nucleobase-containing compound metabolic process | fusion of virus membrane with host plasma membrane | organic substance metabolic process | protein folding | regulation of protein secretion | cell activation | positive regulation of protein transport | signaling | uncoating of virus | cellular protein metabolic process | cellular macromolecule biosynthetic process | organelle organization | cellular protein modification process | regulation of transport | neutrophil mediated immunity | heterocycle metabolic process | protein peptidyl-prolyl isomerization | immune system process | cellular metabolic process | regulation of viral genome replication | cellular response to organic substance | regulation of protein localization | regulation of viral life cycle | signal transduction | macromolecule metabolic process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | adherens junction | focal adhesion | cytoplasmic vesicle | cell | cytoplasmic vesicle lumen | cytoplasm | cell-substrate junction | intracellular organelle | ficolin-1-rich granule lumen | protein-containing complex | secretory vesicle | endomembrane system | vesicle | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cell-substrate adherens junction | secretory granule lumen | cytosol | intracellular vesicle | intracellular | cell junction | membrane | vesicle lumen