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QuickView for PrPSc (gene)


Gene Symbol:
Prnp Mus musculus Mus musculus
Full name:
prion protein
Synonyms:
AA960666, AI325101, CD230, PrP, PrP<C>, PrPC, PrPSc, Prn-i, Prn-p, Sinc, prP27-30, prP33-35C, major prion protein
Genomic Location:
Chr 2: 131735693-131764163
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
NM_011170
NM_001278256
Protein Names
P04925
Q4FJQ7
Q3UG89



GO Molecular Function

peptide binding | amyloid-beta binding | cation binding | G-protein coupled glutamate receptor binding | enzyme binding | protein-containing complex binding | ATP-dependent protein binding | signaling receptor binding | carbohydrate derivative binding | type 5 metabotropic glutamate receptor binding | ion channel binding | chaperone binding | cytoskeletal protein binding | amide binding | signaling receptor activity | identical protein binding | ion binding | cuprous ion binding | copper ion binding | protein binding | G-protein coupled receptor binding | lamin binding | glycosaminoglycan binding | transition metal ion binding | microtubule binding | tubulin binding | protease binding | metal ion binding | glutamate receptor binding | cupric ion binding

GO Biological Process

negative regulation of leukocyte activation | negative regulation of amyloid-beta formation | negative regulation of phosphorylation | protein homooligomerization | regulation of intracellular protein transport | negative regulation of immune system process | negative regulation of activated T cell proliferation | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of localization | modulation of age-related behavioral decline | regulation of programmed cell death | positive regulation of peptidyl-tyrosine phosphorylation | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | response to metal ion | regulation of protein localization to membrane | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | positive regulation of phosphate metabolic process | regulation of neuron death | cellular process | cellular homeostasis | negative regulation of calcineurin-mediated signaling | regulation of calcium-mediated signaling | negative regulation of signaling | neuron projection maintenance | negative regulation of synapse organization | negative regulation of T cell receptor signaling pathway | positive regulation of protein kinase activity | negative regulation of apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | copper ion homeostasis | response to inorganic substance | negative regulation of cellular metabolic process | regulation of T cell receptor signaling pathway | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | negative regulation of calcium-mediated signaling | cellular response to metal ion | response to stimulus | regulation of cellular protein localization | regulation of chloride transport | regulation of long-term synaptic potentiation | regulation of peptidyl-tyrosine phosphorylation | positive regulation of protein metabolic process | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | positive regulation of cellular protein localization | regulation of cell proliferation | negative regulation of interferon-gamma production | response to peptide | protein destabilization | cellular response to inorganic substance | cellular nitrogen compound metabolic process | regulation of protein transport | negative regulation of metabolic process | cellular component assembly | regulation of synapse structure or activity | regulation of peptide transport | modulation of chemical synaptic transmission | regulation of cell adhesion | negative regulation of amyloid precursor protein catabolic process | activation of protein kinase activity | regulation of intracellular transport | metal ion homeostasis | regulation of nucleic acid-templated transcription | regulation of potassium ion transmembrane transport | negative regulation of dendritic spine maintenance | response to nitrogen compound | regulation of calcium ion transport into cytosol | regulation of protein tyrosine kinase activity | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | learning or memory | protein complex oligomerization | regulation of catalytic activity | regulation of phosphorylation | regulation of T cell activation | positive regulation of protein localization to plasma membrane | regulation of activated T cell proliferation | regulation of gene expression | nervous system process | cellular response to peptide | positive regulation of intracellular protein transport | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | regulation of anion channel activity | regulation of synapse organization | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | negative regulation of DNA-binding transcription factor activity | negative regulation of calcineurin-NFAT signaling cascade | negative regulation of interleukin-17 production | response to oxidative stress | second-messenger-mediated signaling | cognition | response to cadmium ion | cellular copper ion homeostasis | regulation of cellular protein metabolic process | regulation of calcium ion transmembrane transport | positive regulation of neuron death | regulation of amyloid precursor protein catabolic process | cation homeostasis | cellular response to drug | negative regulation of cell-cell adhesion | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | negative regulation of cell activation | cellular response to amyloid-beta | regulation of protein metabolic process | negative regulation of interleukin-2 production | homeostatic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | regulation of potassium ion transport | positive regulation of molecular function | calcium-mediated signaling | protein-containing complex assembly | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | negative regulation of cell projection organization | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | cell projection organization | metabolic process | regulation of protein localization to plasma membrane | regulation of protein targeting | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | negative regulation of long-term synaptic potentiation | negative regulation of programmed cell death | regulation of calcium ion import across plasma membrane | chemical homeostasis | behavior | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | response to copper ion | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of calcineurin-NFAT signaling cascade | ion homeostasis | regulation of phosphate metabolic process | regulation of dendritic spine maintenance | regulation of ion transmembrane transport | positive regulation of intracellular transport | regulation of postsynapse organization | positive regulation of protein transport | negative regulation of protein metabolic process | regulation of intracellular calcium activated chloride channel activity | regulation of calcium ion import | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | response to amyloid-beta | regulation of transcription, DNA-templated | regulation of amyloid-beta formation | regulation of T cell proliferation | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | positive regulation of protein tyrosine kinase activity | regulation of cytokine production | regulation of ion transport | developmental process | regulation of calcium ion transport | positive regulation of protein targeting to membrane | calcium-mediated signaling using intracellular calcium source | regulation of transport | negative regulation of cell proliferation | regulation of cell-cell adhesion | response to organonitrogen compound | cellular metal ion homeostasis | heterocycle metabolic process | regulation of anion transport | regulation of glutamate receptor signaling pathway | positive regulation of metabolic process | regulation of synaptic plasticity | regulation of cell projection organization | transition metal ion homeostasis | regulation of interferon-gamma production | negative regulation of lymphocyte proliferation | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | cellular response to copper ion | negative regulation of cell death | aging | regulation of cellular component organization | signal transduction | regulation of signaling | amyloid precursor protein metabolic process | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | organelle membrane | nuclear membrane | cell | organelle outer membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | membrane microdomain | dendritic tree | inclusion body | Golgi apparatus | cell projection | endomembrane system | postsynapse | plasma membrane | nuclear envelope | membrane raft | postsynaptic density | asymmetric synapse | mitochondrion | anchored component of membrane | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | postsynaptic specialization | mitochondrial envelope | cell periphery | outer membrane | mitochondrial membrane | cytosol | cell surface | intracellular | membrane