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QuickView for Prazepam (compound)


PubChem
Name: Prazepam
PubChem Compound ID: 4890
Description: A benzodiazepine that is used in the treatment of ANXIETY DISORDERS.
Molecular formula: C19H17ClN2O
Molecular weight: 324.804 g/mol
Synonyms:
Prazepamum [INN-Latin]; 2H-1, 4-Benzodiazepin-2-one, 1, 3-dihydro-7-chloro-1-(cyclopropylmethyl)-5-phenyl-; 2H-1, 4-Benzodiazepin-2-one, 7-chloro-1- (cyclopropylmethyl)-1, 3-dihydro-5-phenyl-; 7-Chloro-1-(cyclopropylmethyl)-1, 3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one; DEA No. 2764; D00470; Centrax (TN); Trepidan; NSC277179; 2955-38-6.
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DrugBank
Identification
Name: Prazepam
Name (isomeric): DB01588
Drug Type: small molecule
Description: A benzodiazepine that is used in the treatment of ANXIETY DISORDERS.
Synonyms:
Prazepamum [inn-latin]
Brand: Verstran, Sedapran, Demetrin, Settima, Prazeene, Centrax, Lysanxia, Prazene, Trepidan
Category: Anti-anxiety Agents, GABA Modulators, Hypnotics and Sedatives
CAS number: 2955-38-6
Pharmacology
Indication: For the treatment of anxiety disorders.
Pharmacology: Prazepam is a benzodiazepine derivative drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Benzodiazepines may be habit-forming (causing mental or physical dependence), especially when taken for a long time or in high doses.
Mechanism of Action: Prazepam is believed to stimulate GABA receptors in the ascending reticular activating system. Since GABA is inhibitory, receptor stimulation increases inhibition and blocks both cortical and limbic arousal following stimulation of the brain stem reticular formation.
Biotransformation: Hepatic.
Half Life: 36-200 hours
Toxicity: Symptoms of overdose include somnolence, confusion, coma, and diminished reflexes. Respiration, pulse and blood pressure should be monitored.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Avoid alcohol.
Avoid taking with grapefruit juice.
Avoid excessive quantities of coffee or tea (Caffeine).
Take with food.
Drug interaction:
OmeprazoleOmeprazole may increase the effect of the benzodiazepine, prazepam.
CimetidineCimetidine may increase the effect of the benzodiazepine, prazepam.
TriprolidineThe CNS depressants, Triprolidine and Prazepam, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
IndinavirThe protease inhibitor, indinavir, may increase the effect of the benzodiazepine, prazepam.
NelfinavirThe protease inhibitor, nelfinavir, may increase the effect of the benzodiazepine, prazepam.
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