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QuickView for Praziquantel (compound)


PubChem
Name: Praziquantel
PubChem Compound ID: 1917817
Description: An anthelmintic used in most schistosome and many cestode infestations.
Molecular formula: C19H24N2O2
Molecular weight: 312.406 g/mol
Synonyms:
ZINC00403566
DrugBank
Identification
Name: Praziquantel
Name (isomeric): DB01058
Drug Type: small molecule
Description: An anthelmintic used in most schistosome and many cestode infestations.
Brand: Biltricide
Brand name mixture:
Drontal Plus Tabs for Medium and Large Dogs(Febantel + Praziquantel + Pyrantel (Pyrantel Pamoate)), Drontal Tab(Praziquantel + Pyrantel (Pyrantel Pamoate)), Drontal Plus Tablets for Med. And Large Dogs(Febantel + Praziquantel + Pyrantel (Pyrantel Pamoate)), Drontal Plus Tablets for Small Dogs(Febantel + Praziquantel + Pyrantel (Pyrantel Pamoate)...
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Category: Anthelmintics
CAS number: 55268-74-1
Pharmacology
Indication: For the treatment of infections due to all species of schistosoma.
Pharmacology:
Praziquantel is an anthelmintic used in most schistosome and many cestode infestations. Praziquantel effects the permeability of the cell membrane resulting in the contraction of schistosomes. The drug further causes vacuolization and disintegration of the schistosome tegument. The effect is more marked on adult worms compared to young worms. An in...
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Mechanism of Action:
Praziquantel works by causing severe spasms and paralysis of the worms' muscles. This paralysis is accompanied - and probably caused - by a rapid Ca 2+ influx inside the schistosome. Morphological alterations are another early effect of praziquantel. These morphological alterations are accompanied by an increased exposure of schistosome antigens at...
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Absorption: Rapidly absorbed (80%)
Protein binding: 80 to 85%
Biotransformation: renal
Half Life: 0.8-1.5 hours (in serum)
Interactions
Food interaction:
Grapefruit and grapefruit juice should be avoided throughout treatment. Grapefruit can increase serum levels of this product.
Take with food.
Drug interaction:
TelithromycinTelithromycin may reduce clearance of Praziquantel. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Praziquantel if Telithromycin is initiated, discontinued or dose changed.
RifampinSignificant decrease in praziquantel level
CarbamazepineMarkedly lower praziquantel levels
ChloroquineMarkedly lower praziquantel levels
VoriconazoleVoriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of praziquantel by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of praziquantel if voriconazole is initiated, discontinued or dose changed.
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