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QuickView for Proc (gene)


Gene Symbol:
PROC Homo sapiens Homo sapiens
Full name:
protein C, inactivator of coagulation factors Va and VIIIa
Synonyms:
APC, PC, PROC1, THPH3, THPH4, vitamin K-dependent protein C, anticoagulant protein C, autoprothrombin IIA, blood coagulation factor XIV, prepro-protein C, type I protein C
Genomic Location:
Chr 2: 127892487-127903288
Description:
This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thromb...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q14.3





GO Molecular Function

cation binding | hydrolase activity | catalytic activity | serine hydrolase activity | ion binding | protein binding | serine-type endopeptidase activity | serine-type peptidase activity | calcium ion binding | endopeptidase activity | metal ion binding | peptidase activity

GO Biological Process

proteolysis | regulation of cell development | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | positive regulation of developmental process | intracellular transport | cellular process | negative regulation of inflammatory response | localization | hemostasis | negative regulation of apoptotic process | establishment of localization in cell | regulation of cell differentiation | positive regulation of endothelial cell differentiation | negative regulation of wound healing | regulation of cellular process | regulation of apoptotic process | hepaticobiliary system development | response to stimulus | response to stress | regulation of epithelial cell differentiation | cellular localization | regulation of wound healing | protein modification process | macromolecule modification | blood coagulation | system development | nitrogen compound metabolic process | multicellular organism development | wound healing | liver development | regulation of blood coagulation | vesicle-mediated transport | positive regulation of cell differentiation | negative regulation of response to wounding | regulation of establishment of endothelial barrier | Golgi vesicle transport | positive regulation of establishment of endothelial barrier | coagulation | protein metabolic process | gland development | response to wounding | anatomical structure development | metabolic process | positive regulation of cell development | regulation of body fluid levels | negative regulation of programmed cell death | organic substance metabolic process | animal organ development | serine-type endopeptidase activity | serine-type peptidase activity | regulation of response to wounding | ER to Golgi vesicle-mediated transport | endopeptidase activity | cellular protein metabolic process | regulation of developmental process | developmental process | cellular protein modification process | negative regulation of coagulation | positive regulation of epithelial cell differentiation | regulation of endothelial cell differentiation | regulation of circulating fibrinogen levels | negative regulation of blood coagulation | cellular metabolic process | peptidase activity | regulation of cell death | negative regulation of cell death | regulation of inflammatory response | post-translational protein modification | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | endomembrane system | endoplasmic reticulum lumen | extracellular region | membrane-bounded organelle | organelle | extracellular space | membrane-enclosed lumen | intracellular | Golgi lumen