Name: | Propantheline |
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PubChem Compound ID: | 4934 |
Description: | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. |
Molecular formula: | C23H30NO3+ |
Molecular weight: | 368.489 g/mol |
Synonyms: |
KBioSS_001350; DivK1c_000802; Ammonium, (2-hydroxyethyl)diisopropylmethyl-, xanthene-9-carboxylate (ester); Propanthelinum; Spectrum2_001300; Spectrum_000870; KBio3_001764; Prestwick0_000827; Spectrum3_000882; HSDB 3174.
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Name: | Propantheline |
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Name (isomeric): | DB00782 |
Drug Type: | small molecule |
Description: | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. |
Synonyms: |
Propantheline Bromide; Propanthelinum; Propanthelinium
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Brand: | Propanthel, Pro-Banthine |
Category: | Muscarinic Antagonists, Anti-Ulcer Agents, Antispasmodics, Antimuscarinics |
CAS number: | 298-50-0 |
Indication: | For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder. |
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Pharmacology: |
Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscl...
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Mechanism of Action: | Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic). |
Route of elimination: | Approximately 70% of the dose is excreted in the urine, mostly as metabolites. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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