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QuickView for Propantheline (compound)


PubChem
Name: Propantheline
PubChem Compound ID: 4934
Description: A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Molecular formula: C23H30NO3+
Molecular weight: 368.489 g/mol
Synonyms:
KBioSS_001350; DivK1c_000802; Ammonium, (2-hydroxyethyl)diisopropylmethyl-, xanthene-9-carboxylate (ester); Propanthelinum; Spectrum2_001300; Spectrum_000870; KBio3_001764; Prestwick0_000827; Spectrum3_000882; HSDB 3174.
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DrugBank
Identification
Name: Propantheline
Name (isomeric): DB00782
Drug Type: small molecule
Description: A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Synonyms:
Propantheline Bromide; Propanthelinum; Propanthelinium
Brand: Propanthel, Pro-Banthine
Category: Muscarinic Antagonists, Anti-Ulcer Agents, Antispasmodics, Antimuscarinics
CAS number: 298-50-0
Pharmacology
Indication: For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
Pharmacology:
Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscl...
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Mechanism of Action: Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Route of elimination: Approximately 70% of the dose is excreted in the urine, mostly as metabolites.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TriprolidineTriprolidine and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
DonepezilPossible antagonism of action
TrimethobenzamideTrimethobenzamide and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
HaloperidolThe anticholinergic increases the risk of psychosis and tardive dyskinesia
GalantaminePossible antagonism of action
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Targets