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QuickView for Propantheline (compound)

Summary
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PubChem

PubChem Compound 4934

PubChem Compound 4934

Name:	Propantheline
PubChem Compound ID:	4934
Description:	A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Molecular formula:	C₂₃H₃₀NO₃⁺
Molecular weight:	368.489 g/mol
Synonyms:	KBioSS_001350; DivK1c_000802; Ammonium, (2-hydroxyethyl)diisopropylmethyl-, xanthene-9-carboxylate (ester); Propanthelinum; Spectrum2_001300; Spectrum_000870; KBio3_001764; Prestwick0_000827; Spectrum3_000882; HSDB 3174. show more » KBioSS_001350; DivK1c_000802; Ammonium, (2-hydroxyethyl)diisopropylmethyl-, xanthene-9-carboxylate (ester); Propanthelinum; Spectrum2_001300; Spectrum_000870; KBio3_001764; Prestwick0_000827; Spectrum3_000882; HSDB 3174; Spectrum4_000973; Prestwick1_000827; NCGC00015854-01; 298-50-0; SPBio_001339; NINDS_000802; KBioGR_001345; propantheline; C07506; Lopac-P-8891; KBio2_003918; KBio1_000802; EINECS 206-063-2; CAS-50-34-0; KBio2_006486; NCGC00016219-01; 2-Propanaminium, N-methyl-N-(1-methylethyl)-N-(2-((9H-xanthen-9-ylcarbonyl)oxy)ethyl)-; KBio2_001350; Propanthelinium; SPBio_002674 show less «

DrugBank

Identification

Name:	Propantheline
Name (isomeric):	DB00782
Drug Type:	small molecule
Description:	A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Synonyms:	Propantheline Bromide; Propanthelinum; Propanthelinium
Brand:	Propanthel, Pro-Banthine
Category:	Muscarinic Antagonists, Anti-Ulcer Agents, Antispasmodics, Antimuscarinics
CAS number:	298-50-0

Pharmacology

Indication:	For the treatment of enuresis. It has also been used for hyperhidrosis, and cramps or spasms of the stomach, intestines or bladder.
Pharmacology:	Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscl... show more » Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Propantheline inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. show less «
Mechanism of Action:	Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
Route of elimination:	Approximately 70% of the dose is excreted in the urine, mostly as metabolites.
Affected organisms:	Humans and other mammals

Interactions

Drug interaction:

Triprolidine	Triprolidine and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Donepezil	Possible antagonism of action
Trimethobenzamide	Trimethobenzamide and Propantheline, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Haloperidol	The anticholinergic increases the risk of psychosis and tardive dyskinesia
Galantamine	Possible antagonism of action

Targets

Muscarinic acetylcholine receptor M1