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QuickView for Propericiazine (compound)


PubChem
Name: periciazine
PubChem Compound ID: 4747
Molecular formula: C21H23N3OS
Molecular weight: 365.493 g/mol
Synonyms:
6909 RP; Bayer 1409; SPBio_001607; D01485; Nemactil; Periciazinum [INN-Latin]; Spectrum2_001604; KBio1_000874; Periciazina [INN-Spanish]; IC 6002.
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DrugBank
Identification
Name: periciazine
Name (isomeric): DB01608
Drug Type: small molecule
Synonyms:
Pericyazine
Brand: Neuleptil, Yaz
Category: Phenothiazines, Antipsychotic Agents
CAS number: 2622-26-6
Pharmacology
Indication: For use as adjunctive medication in some psychotic patients. Propericiazine (Pericyazine)is used for the control of residual prevailing hostility, impulsiveness and aggressiveness.
Pharmacology:
Pericyazine is a phenothiazine of the piperidine group. It has been shown to reduce pathologic arousal and affective tension in some psychotic patients, while the symptoms of abnormal mental integration are relatively unaffected. It is a sedative phenothiazine with weak antipsychotic properties. It also has adrenolytic, anticholinergic, metabolic a...
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Mechanism of Action: Pericyazine, like other phenothiazines, is presumed to act principally in the subcortical areas, by producing what has been described as a central adrenergic blockade of the alpha adrenergic receptors as well as antagonism of the D(1) dopamine receptor.
Toxicity: In milder cases of phenothiazine overdosage the patient may be agitated, delirious and confused. Frequently he is lethargic or in a comatose state. Twitching, dystonic movements or convulsions may be present and hypotension, cardiovascular collapse, arrhythmias and hypothermia might be observed.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Take with food to reduce irritation. Avoid alcohol.
Drug interaction:
BenzphetamineAntipsychotics may diminish the stimulatory effect of Amphetamines. Monitor effectiveness of amphetamine therapy when altering concurrent antipsychotic therapy as antipsychotic agents may impair the stimulatory effect of amphetamines.
MethamphetamineDecreased anorexic effect, may increase pyschotic symptoms
MetrizamideIncreased risk of convulsions
PhenylpropanolamineDecreased anorexic effect, may increase psychotic symptoms.
TerfenadineIncreased risk of cardiotoxicity and arrhythmias
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Targets