QuickView for Ptgds (gene)

Gene Symbol:

PTGDS Homo sapiens

Full name:

prostaglandin D2 synthase

Synonyms:

L-PGDS, LPGDS, PDS, PGD2, PGDS, PGDS2, prostaglandin-H2 D-isomerase, PGD2 synthase, beta-trace protein, cerebrin-28, glutathione-independent PGD synthase, glutathione-independent PGD synthetase, lipocalin-type prostaglandin D synthase, prostaglandin D synthase, prostaglandin D2 synthase 21kDa (brain), testis tissue sperm-binding protein Li 63n

Genomic Location:

Chr 9: 138991777-138996015

Description:

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibit...

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The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGNNNNNNKCCAR_UNKNOWN ,  CACCCBINDINGFACTOR_Q6 ,  NF1_Q6 ,  NF1_Q6_01 ,  AP2REP_01 ,  HEN1_02 ,  CTGCAGY_UNKNOWN ,  CAGCTG_AP4_Q5 ,  GGGTGGRR_PAX4_03

Cytogenetic Map:

9q34.3

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