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QuickView for Pum2 (gene)


Gene Symbol:
PUM2 Homo sapiens Homo sapiens
Full name:
pumilio RNA binding family member 2
Synonyms:
PUMH2, PUML2, pumilio homolog 2, pumilio-2
Genomic Location:
Chr 2: 20311934-20390625
Description:
This gene encodes a protein that belongs to a family of RNA-binding proteins. The encoded protein functions as a translational repressor during embryonic development and cell differentiation. This protein is also thought to be a positive regulator of cell proliferation in adipose-derived stem cells. Alternate splicing results in multiple transcript...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Danio rerio Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-1 Predicted Gene Targets for miR-10 Predicted Gene Targets for miR-101 Predicted Gene Targets for miR-134 Predicted Gene Targets for miR-144 Predicted Gene Targets for miR-200b Predicted Gene Targets for miR-218 Predicted Gene Targets for miR-219 Predicted Gene Targets for miR-224 Predicted Gene Targets for miR-23
Cytogenetic Map:
chr 2
2p24.1





GO Molecular Function

nucleic acid binding | mRNA binding | miRNA binding | organic cyclic compound binding | protein binding | mRNA 3'-UTR binding | heterocyclic compound binding | RNA binding

GO Biological Process

positive regulation of immune response | RNA metabolic process | gene silencing by RNA | RNA processing | regulation of immune system process | production of small RNA involved in gene silencing by RNA | regulation of chromosome segregation | cellular process | regulation of gene expression, epigenetic | positive regulation of immune effector process | dsRNA fragmentation | regulation of defense response to virus | regulation of RIG-I signaling pathway | regulation of mRNA stability | regulation of immune response | regulation of cellular process | gene silencing | regulation of metabolic process | production of miRNAs involved in gene silencing by miRNA | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | cellular component organization | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | posttranscriptional regulation of gene expression | regulation of gene silencing | cellular nitrogen compound metabolic process | cellular response to organic cyclic compound | negative regulation of metabolic process | cellular component assembly | response to nitrogen compound | organelle assembly | nitrogen compound metabolic process | regulation of signal transduction | response to dsRNA | regulation of gene expression | gene silencing by miRNA | positive regulation of RIG-I signaling pathway | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | regulation of RNA stability | regulation of cellular protein metabolic process | cellular protein-containing complex assembly | posttranscriptional gene silencing | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cellular response to dsRNA | regulation of RNA metabolic process | protein-containing complex assembly | posttranscriptional gene silencing by RNA | response to organic substance | regulation of innate immune response | regulation of intracellular signal transduction | metabolic process | regulation of gene silencing by RNA | stress granule assembly | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of gene expression | regulation of mRNA catabolic process | gene expression | ribonucleoprotein complex assembly | positive regulation of cytokine production | regulation of cell communication | response to organic cyclic compound | regulation of cytokine production | positive regulation of gene silencing by miRNA | organelle organization | heterocycle metabolic process | ribonucleoprotein complex biogenesis | cellular metabolic process | cellular response to organic substance | regulation of translation | positive regulation of signaling | regulation of signaling | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cytoplasmic stress granule | nuclear membrane | cell | ribonucleoprotein granule | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | nuclear envelope | ribonucleoprotein complex | perinuclear region of cytoplasm | membrane-bounded organelle | nucleus | organelle | cytoplasmic ribonucleoprotein granule | cytosol | intracellular | membrane