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QuickView for QDPR (gene)


Gene Symbol:
QDPR Homo sapiens Homo sapiens
Full name:
quinoid dihydropteridine reductase
Synonyms:
DHPR, PKU2, SDR33C1, dihydropteridine reductase, 6,7-dihydropteridine reductase, HDHPR, short chain dehydrogenase/reductase family 33C member 1, testis secretory sperm-binding protein Li 236P
Genomic Location:
Chr 4: 17097121-17154822
Description:
This gene encodes the enzyme dihydropteridine reductase, which catalyzes the NADH-mediated reduction of quinonoid dihydrobiopterin. This enzyme is an essential component of the pterin-dependent aromatic amino acid hydroxylating systems. Mutations in this gene resulting in QDPR deficiency include aberrant splicing, amino acid substitutions, inserti...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 4
4p15.32





GO Molecular Function

NADP binding | cofactor binding | 6,7-dihydropteridine reductase activity | oxidoreductase activity, acting on the CH-NH group of donors | nucleotide binding | coenzyme binding | catalytic activity | anion binding | NADH binding | electron transfer activity | identical protein binding | ion binding | organic cyclic compound binding | protein binding | protein homodimerization activity | NAD binding | protein dimerization activity | NADPH binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

response to hormone | 6,7-dihydropteridine reductase activity | response to metal ion | pteridine-containing compound biosynthetic process | response to drug | generation of precursor metabolites and energy | polyol metabolic process | cellular amino acid catabolic process | cellular process | oxidoreductase activity, acting on the CH-NH group of donors | organic substance catabolic process | aromatic amino acid family metabolic process | response to inorganic substance | response to peptide hormone | cellular amino acid metabolic process | catabolic process | hepaticobiliary system development | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | tetrahydrobiopterin biosynthetic process | response to stimulus | dihydrobiopterin metabolic process | carboxylic acid catabolic process | cellular nitrogen compound biosynthetic process | alcohol metabolic process | electron transport chain | response to peptide | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular biosynthetic process | pteridine-containing compound metabolic process | drug catabolic process | organic hydroxy compound metabolic process | response to nitrogen compound | system development | nitrogen compound metabolic process | coenzyme biosynthetic process | multicellular organism development | electron transfer activity | L-phenylalanine catabolic process | cofactor biosynthetic process | liver development | small molecule metabolic process | tetrahydrobiopterin metabolic process | biosynthetic process | diol biosynthetic process | aromatic compound biosynthetic process | cellular response to drug | aromatic compound catabolic process | drug metabolic process | carboxylic acid metabolic process | response to glucagon | response to organic substance | gland development | L-phenylalanine metabolic process | anatomical structure development | metabolic process | oxidation-reduction process | organic substance metabolic process | animal organ development | aromatic amino acid family catabolic process | organonitrogen compound catabolic process | organic acid metabolic process | developmental process | response to organonitrogen compound | heterocycle metabolic process | response to aluminum ion | response to lead ion | cellular metabolic process | oxidoreductase activity | multicellular organismal process

GO Cellular Component

neuron projection | cell | cytoplasm | cell projection | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular