QuickView for QPRT (gene)
- Gene Symbol:
- QPRT
Homo sapiens - Full name:
- quinolinate phosphoribosyltransferase
- Synonyms:
- HEL-S-90n, QPRTase, nicotinate-nucleotide pyrophosphorylase [carboxylating], epididymis secretory sperm binding protein Li 90n, nicotinate-nucleotide pyrophosphorylase (carboxylating)
- Genomic Location:
- Chr 16: 29597942-29616816
- Description:
-
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's di...
- Orthologs:
- Mus musculus , Rattus norvegicus , Saccharomyces cerevisiae , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
16p11.2
GO Molecular Function
catalytic activity | identical protein binding | transferase activity, transferring glycosyl groups | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring pentosyl groups | transferase activity | nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO Biological Process
nicotinamide nucleotide biosynthetic process | cellular process | organic substance catabolic process | dicarboxylic acid metabolic process | nucleotide metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | quinolinate metabolic process | dicarboxylic acid catabolic process | carboxylic acid catabolic process | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular component assembly | quinolinate catabolic process | cellular biosynthetic process | drug catabolic process | nucleotide biosynthetic process | nitrogen compound metabolic process | coenzyme biosynthetic process | phosphorus metabolic process | protein complex oligomerization | NAD biosynthetic process | organophosphate metabolic process | cofactor biosynthetic process | small molecule metabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | aromatic compound biosynthetic process | phosphate-containing compound metabolic process | drug metabolic process | carboxylic acid metabolic process | pyridine nucleotide biosynthetic process | protein-containing complex assembly | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | organonitrogen compound catabolic process | organic acid metabolic process | nicotinamide nucleotide metabolic process | NAD metabolic process | heterocycle metabolic process | cellular metabolic process
GO Cellular Component
cell | cytoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cytosol | intracellular
