Name: | Quinacrine |
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PubChem Compound ID: | 149640 |
Description: | An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. |
Molecular formula: | C25H34ClN3O3 |
Molecular weight: | 460.009 g/mol |
Synonyms: |
Quinacrine acetate; N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine monoacetate; 83-89-6; 78901-94-7; 1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, monoacetate
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Name: | Quinacrine |
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Name (isomeric): | DB01103 |
Drug Type: | small molecule |
Description: | An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. |
Synonyms: |
Quinacrine Dihydrochloride
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Brand: | Atebrin, Erion, Italchine, Quinactine, Erion Hydrochloride, Atabrine, Antimalarina, Atebrine, Acrinamine, Mepacrine, Haffkinine, Acrichine, Acriquine, Akrichin |
Category: | Antimalarials, Antineoplastic Agents, Antiprotozoals, Enzyme Inhibitors, Antihelmintics, Antinematodal Agents, Anticestodal Agents |
CAS number: | 83-89-6 |
Indication: | For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions. |
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Pharmacology: |
Quinacrine has been used as an antimalarial drug and as an antibiotic. It is used to treat giardiasis, a protozoal infection of the intestinal tract, and certain types of lupus erythematosus, an inflammatory disease that affects the joints, tendons, and other connective tissues and organs. Quinacrine may be injected into the space surrounding the l...
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Mechanism of Action: |
The exact mechanism of antiparasitic action is unknown; however, quinacrine binds to deoxyribonucleic acid (DNA) in vitro by intercalation between adjacent base pairs, inhibiting transcription and translation to ribonucleic acid (RNA). Quinacrine does not appear to localize to the nucleus of Giaridia trophozoites, suggesting that DNA binding may no...
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Absorption: | Absorbed rapidly from the gastrointestinal tract following oral administration. |
Protein binding: | 80-90% |
Half Life: | 5 to 14 days |
Toxicity: | Oral, rat: LD50 = 900 mg/kg; Oral, mouse: LD50 = 1000 mg/kg. Symptoms of overdose include seizures, hypotension, cardiac arrhythmias, and cardiovascular collapse. |
Affected organisms: | Parasitic protozoa and helminths |
Drug interaction: |
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