Name: | quinethazone |
---|---|
PubChem Compound ID: | 6307 |
Molecular formula: | C10H12ClN3O3S |
Molecular weight: | 289.739 g/mol |
Synonyms: |
Hydromox; Quinethazonum; Quinethazon; Chinethazonum; 5-25-09-00214 (Beilstein Handbook Reference); Prestwick0_001050; Prestwick1_001050; Quinethazone; Quinethazonum [INN-Latin]; Quinethazone [BAN:INN:JAN].
show more » |
Name: | quinethazone |
---|---|
Name (isomeric): | DB01325 |
Drug Type: | small molecule |
Synonyms: |
Quinethazon; Quinetazona [inn-spanish]; Chinetazone [dcit]; Chinethazonum; Quinethazonum [inn-latin]
|
Brand: | Hydromox, Aquamox, Idrokin |
Brand name mixture: | Hydromox R(Quinethazone + Reserpine) |
Category: | Diuretics, Thiazide, Antihypertensive Agents |
CAS number: | 73-49-4 |
Indication: | Used to treat hypertension. |
---|---|
Pharmacology: |
Quinethazone is a thiazide diuretic used to treat hypertension. It inhibits Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to...
show more » |
Mechanism of Action: |
As a diuretic, quinethazone inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like quinethazone also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chlorid...
show more » |
Affected organisms: | Humans and other mammals |
Food interaction: |
| |
---|---|---|
Drug interaction: |