Bookmark
Forward
QuickView for Quinupristin (compound)
PubChem
| Name: | quinupristin |
|---|---|
| PubChem Compound ID: | 11979364 |
| Molecular formula: | C53H67N9O10S |
| Molecular weight: | 1022.22 g/mol |
DrugBank
Identification
| Name: | quinupristin |
|---|---|
| Name (isomeric): | DB01369 |
| Drug Type: | small molecule |
| Brand name mixture: | Synercid(Dalfopristin + Quinupristin) |
| Category: | Antibacterial Agents |
| CAS number: | 120138-50-3 |
Pharmacology
| Indication: | For the treatment of bacterial infections (usually in combination with dalfopristin). |
|---|---|
| Pharmacology: | Quinupristin is a streptogramin antibiotic, derived from pristinamycin I. By inhibiting the bacterial ribosomal subunits, protein synthesis is inhibited thus leading to eventual bacterial cell death or stasis. |
| Mechanism of Action: |
Quinupristin inhibits the late phase of protein synthesis in the bacterial ribosome. Dalfopristin binds to the 23S portion of the 50S ribosomal subunit, and changes the conformation it, enhancing the binding of quinupristin by a factor of about 100. In addition, it inhibits peptidyl transferase. Quinupristin binds to a nearby site on the 50S riboso...
show more » |
| Protein binding: | Moderate. |
| Biotransformation: | Quinupristin is converted to two conjugated active major metabolites, one with glutathione and one with cysteine. |
| Half Life: | 3.1 hours |
| Affected organisms: | Enteric bacteria and other eubacteria |
Interactions
| Drug interaction: |
|
|---|
Targets
