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QuickView for RAD18 (gene)

Gene Symbol:
RAD18 Homo sapiens Homo sapiens
Full name:
RAD18, E3 ubiquitin protein ligase
RNF73, E3 ubiquitin-protein ligase RAD18, RAD18 homolog, RAD18, S. cerevisiae, homolog, RING finger protein 73, RING-type E3 ubiquitin transferase RAD18, hHR18, hRAD18, postreplication repair protein RAD18, postreplication repair protein hRAD18p
Genomic Location:
Chr 3: 8896560-8980146
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast...
Mus musculus Rattus norvegicus Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3

Transcripts Names
Protein Names

GO Molecular Function

single-stranded DNA-dependent ATPase activity | cation binding | DNA secondary structure binding | enzyme binding | nucleic acid binding | protein-containing complex binding | hydrolase activity | Y-form DNA binding | ATPase activity | pyrophosphatase activity | catalytic activity | polyubiquitin modification-dependent protein binding | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | modification-dependent protein binding | nucleoside-triphosphatase activity | ATPase activity, coupled | DNA binding | identical protein binding | ubiquitin protein ligase activity | damaged DNA binding | ion binding | organic cyclic compound binding | protein binding | ubiquitin protein ligase binding | ubiquitin-protein transferase activity | hydrolase activity, acting on acid anhydrides | transferase activity | ubiquitin-like protein ligase activity | DNA-dependent ATPase activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

GO Biological Process

response to radiation | detection of stimulus | negative regulation of cellular process | regulation of chromosome segregation | cellular process | postreplication repair | regulation of cellular process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to UV | response to stimulus | response to stress | cellular nitrogen compound metabolic process | protein modification process | macromolecule modification | DNA repair | response to light stimulus | nitrogen compound metabolic process | protein monoubiquitination | cellular response to DNA damage stimulus | cellular response to stress | protein modification by small protein conjugation | ubiquitin protein ligase activity | protein metabolic process | protein ubiquitination | DNA metabolic process | protein autoubiquitination | DNA damage response, detection of DNA damage | metabolic process | ubiquitin-protein transferase activity | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of chromosome segregation | protein modification by small protein conjugation or removal | cellular protein metabolic process | cellular protein modification process | heterocycle metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | macromolecule metabolic process

GO Cellular Component

nuclear inclusion body | site of DNA damage | chromosome | intracellular membrane-bounded organelle | catalytic complex | microtubule organizing center | cell | nuclear lumen | replication fork | cytoplasm | intracellular organelle | ubiquitin ligase complex | nuclear body | inclusion body | centrosome | protein-containing complex | nucleoplasm | transferase complex | microtubule cytoskeleton | site of double-strand break | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | Rad6-Rad18 complex | intracellular