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QuickView for RAD21 (gene)


Gene Symbol:
RAD21 Homo sapiens Homo sapiens
Full name:
RAD21 cohesin complex component
Synonyms:
CDLS4, HR21, HRAD21, MCD1, NXP1, SCC1, hHR21, double-strand-break repair protein rad21 homolog, NXP-1, RAD21 homolog, SCC1 homolog, kleisin, nuclear matrix protein 1, protein involved in DNA double-strand break repair, sister chromatid cohesion 1
Genomic Location:
Chr 8: 117927355-117956182
Description:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 8
8q24.11


Transcripts Names
NM_006265



GO Molecular Function

RNA polymerase II transcription factor activity, sequence-specific DNA binding | protein-containing complex binding | chromatin binding | protein binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | double-strand break repair | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of cellular component organization | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | regulation of organelle organization | regulation of chromosome segregation | positive regulation of cellular biosynthetic process | cellular process | localization | regulation of mitotic nuclear division | regulation of chromosome separation | macromolecule localization | negative regulation of chromosome segregation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of mitotic metaphase/anaphase transition | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | response to stimulus | regulation of mitotic cell cycle phase transition | chromosome segregation | response to stress | negative regulation of G2/M transition of mitotic cell cycle | cellular nitrogen compound biosynthetic process | regulation of cell cycle phase transition | programmed cell death | reproduction | cellular localization | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | DNA recombination | DNA repair | regulation of nucleic acid-templated transcription | apoptotic process | regulation of cell cycle G2/M phase transition | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | negative regulation of cell cycle G2/M phase transition | sister chromatid segregation | cellular response to DNA damage stimulus | positive regulation of chromosome organization | positive regulation of cell cycle | regulation of gene expression | cellular response to stress | cell cycle | positive regulation of cellular metabolic process | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of mitotic nuclear division | biosynthetic process | cell division | aromatic compound biosynthetic process | nuclear chromosome segregation | protein localization to chromatin | regulation of cellular metabolic process | negative regulation of mitotic sister chromatid segregation | positive regulation of sister chromatid cohesion | negative regulation of mitotic sister chromatid separation | regulation of RNA metabolic process | regulation of mitotic cell cycle | regulation of sister chromatid cohesion | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | DNA metabolic process | reciprocal meiotic recombination | regulation of sister chromatid segregation | nuclear division | metabolic process | regulation of RNA biosynthetic process | negative regulation of mitotic cell cycle | cellular protein localization | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | gene expression | positive regulation of chromosome segregation | regulation of chromosome organization | transcription, DNA-templated | meiosis I | negative regulation of cell cycle | regulation of mitotic sister chromatid segregation | meiotic cell cycle | negative regulation of chromosome organization | regulation of transcription, DNA-templated | protein localization | cellular macromolecule localization | cellular macromolecule biosynthetic process | homologous recombination | organelle organization | positive regulation of cell cycle process | sister chromatid cohesion | positive regulation of transcription, DNA-templated | regulation of mitotic metaphase/anaphase transition | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | negative regulation of cell cycle process | regulation of cellular component organization | protein localization to chromosome | positive regulation of gene expression | macromolecule metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | chromatin | meiotic cohesin complex | cohesin complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear matrix | cytosol | intracellular | membrane | nuclear periphery | condensed chromosome