QuickView for RAD51 (gene)

Gene Symbol:

RAD51 Homo sapiens

Full name:

RAD51 recombinase

Synonyms:

BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2, RAD51A, RECA, DNA repair protein RAD51 homolog 1, BRCA1/BRCA2-containing complex, subunit 5, RAD51 homolog A, RecA, E. coli, homolog of, RecA-like protein, recombination protein A

Genomic Location:

Chr 15: 38774651-38811648

Description:

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play role...

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The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E2F1_Q4_01 ,  E2F_Q6_01 ,  E2F1_Q4 ,  E2F_Q6 ,  E2F1_Q6_01 ,  E2F_Q4 ,  E2F_03 ,  E2F_Q4_01 ,  E2F1DP1RB_01 ,  E2F_Q3 ,  E2F_Q3_01

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Cytogenetic Map:

15q15.1

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