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QuickView for RANGAP1;jsessionid=562B6C1952953A79C1EF0B64E675CD7D (gene)


Gene Symbol:
RANGAP1 Homo sapiens Homo sapiens
Full name:
Ran GTPase activating protein 1
Synonyms:
Fug1, RANGAP, SD, ran GTPase-activating protein 1, segregation distorter homolog, segregation distortion
Genomic Location:
Chr 22: 39971561-40012162
Description:
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 22
22q13.2





GO Molecular Function

enzyme activator activity | GTPase binding | cadherin binding | GTPase activator activity | enzyme binding | nucleic acid binding | GTPase regulator activity | Ras GTPase binding | molecular function regulator | ubiquitin-like protein ligase binding | organic cyclic compound binding | cell adhesion molecule binding | protein binding | ubiquitin protein ligase binding | Ran GTPase binding | small GTPase binding | enzyme regulator activity | heterocyclic compound binding | RNA binding

GO Biological Process

maintenance of protein location in nucleus | negative regulation of intracellular transport | activation of GTPase activity | regulation of intracellular protein transport | regulation of cellular localization | enzyme activator activity | regulation of localization | response to hormone | positive regulation of GTPase activity | cellular process | localization | GTPase activator activity | macromolecule localization | positive regulation of catalytic activity | regulation of protein export from nucleus | negative regulation of establishment of protein localization | response to peptide hormone | regulation of cellular process | cellular response to organonitrogen compound | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | GTPase regulator activity | negative regulation of intracellular protein transport | response to stress | response to peptide | protein localization to nucleus | cellular localization | maintenance of protein localization in organelle | negative regulation of transport | regulation of protein transport | regulation of peptide transport | regulation of intracellular transport | molecular function regulator | response to nitrogen compound | cellular response to hormone stimulus | cellular response to peptide hormone stimulus | regulation of catalytic activity | negative regulation of cellular protein localization | cellular response to peptide | cellular response to vasopressin | response to axon injury | protein localization to organelle | positive regulation of hydrolase activity | negative regulation of protein export from nucleus | regulation of GTPase activity | maintenance of protein location | cell communication | positive regulation of molecular function | regulation of nucleocytoplasmic transport | regulation of establishment of protein localization | response to organic substance | response to wounding | response to vasopressin | cellular protein localization | maintenance of protein location in cell | signaling | protein localization | enzyme regulator activity | cellular macromolecule localization | regulation of transport | response to organonitrogen compound | cellular response to organic substance | regulation of protein localization | signal transduction | maintenance of location in cell

GO Cellular Component

chromosome | dendrite | intracellular membrane-bounded organelle | neuron projection | somatodendritic compartment | organelle membrane | nuclear membrane | chromosome, centromeric region | condensed chromosome, centromeric region | cell | nuclear lumen | kinetochore | cytoplasm | spindle | intracellular organelle | dendritic tree | inclusion body | protein-containing complex | cell projection | endomembrane system | nucleoplasm | plasma membrane bounded cell projection cytoplasm | nuclear envelope | condensed chromosome kinetochore | perinuclear region of cytoplasm | microtubule cytoskeleton | cytoplasmic region | membrane-bounded organelle | aggresome | nucleus | organelle | axon cytoplasm | nuclear pore cytoplasmic filaments | axon | membrane-enclosed lumen | cytoplasmic periphery of the nuclear pore complex | nuclear pore | cytosol | cytoskeleton | intracellular | mitotic spindle | membrane | condensed chromosome