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QuickView for RANKL (gene)


Gene Symbol:
TNFSF11 Homo sapiens Homo sapiens
Full name:
TNF superfamily member 11
Synonyms:
CD254, ODF, OPGL, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2, sOdf, tumor necrosis factor ligand superfamily member 11, TNF-related activation-induced cytokine, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa B ligand, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor ligand 6B, tumor necrosis factor superfamily member 11
Genomic Location:
Chr 13: 42043795-42080148
Description:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was re...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Bos taurus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 13
13q14.11





GO Molecular Function

signaling receptor binding | cytokine receptor binding | molecular function regulator | tumor necrosis factor receptor binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | tumor necrosis factor receptor superfamily binding

GO Biological Process

regulation of JUN kinase activity | regulation of ERK1 and ERK2 cascade | protein homooligomerization | positive regulation of macromolecule biosynthetic process | positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling | response to cytokine | cell motility | intracellular signal transduction | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | positive regulation of bone development | regulation of immune system process | myeloid cell differentiation | positive regulation of developmental process | regulation of MAP kinase activity | cellular response to tumor necrosis factor | positive regulation of lymphocyte activation | bone development | cell differentiation | bone remodeling | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of peptide hormone secretion | tissue homeostasis | regulation of lipid transport | regulation of bone remodeling | positive regulation of cellular biosynthetic process | cellular process | localization | odontogenesis | tissue remodeling | regulation of corticotropin-releasing hormone secretion | immune system development | positive regulation of protein kinase activity | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | myeloid cell development | tissue development | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | anatomical structure homeostasis | regulation of protein kinase B signaling | regulation of cellular process | regulation of osteoclast development | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | positive regulation of cellular protein metabolic process | bone resorption | epithelium development | cellular component organization | MAPK cascade | calcium ion homeostasis | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | JNK cascade | positive regulation of osteoclast differentiation | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | multicellular organismal homeostasis | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | positive regulation of hormone secretion | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | monocyte chemotaxis | hemopoiesis | cellular component assembly | TNFSF11-mediated signaling pathway | protein modification process | regulation of peptide transport | regulation of cell adhesion | macromolecule modification | cell-cell signaling | cell chemotaxis | activation of protein kinase activity | molecular function regulator | metal ion homeostasis | stress-activated protein kinase signaling cascade | regulation of fever generation | leukocyte migration | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | leukocyte differentiation | regulation of cellular response to stress | locomotion | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of icosanoid secretion | multicellular organism development | cell migration | positive regulation of corticotropin-releasing hormone secretion | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | mammary gland development | protein complex oligomerization | positive regulation of protein kinase B signaling | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of acute inflammatory response | regulation of T cell activation | mammary gland lobule development | regulation of gene expression | osteoclast differentiation | positive regulation of secretion | cellular response to stress | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | positive regulation of fever generation by positive regulation of prostaglandin secretion | positive regulation of heat generation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | paracrine signaling | positive regulation of cell differentiation | second-messenger-mediated signaling | positive regulation of myeloid cell differentiation | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | stress-activated MAPK cascade | regulation of cellular protein metabolic process | phosphorylation | mammary gland epithelial cell proliferation | positive regulation of lipid localization | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | homeostatic process | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | positive regulation of peptide hormone secretion | positive regulation of molecular function | calcium-mediated signaling | activation of MAPK activity | regulation of signaling receptor activity | receptor regulator activity | protein-containing complex assembly | protein metabolic process | positive regulation of protein modification process | response to organic substance | gland development | regulation of homotypic cell-cell adhesion | osteoclast proliferation | regulation of hemopoiesis | epithelial cell proliferation | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | regulation of bone development | anatomical structure development | cell surface receptor signaling pathway | metabolic process | positive regulation of cell development | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of bone resorption | regulation of tissue remodeling | chemical homeostasis | regulation of secretion | receptor ligand activity | immune response | cytokine activity | organic substance metabolic process | positive regulation of acute inflammatory response | animal organ development | positive regulation of ion transport | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | tumor necrosis factor-mediated signaling pathway | ion homeostasis | osteoclast development | regulation of phosphate metabolic process | mammary gland epithelium development | positive regulation of organic acid transport | regulation of JNK cascade | positive regulation of MAPK cascade | mammary gland alveolus development | regulation of osteoclast differentiation | positive regulation of fever generation | regulation of stress-activated MAPK cascade | regulation of cell communication | cellular response to leukemia inhibitory factor | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | cell development | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | positive regulation of MAP kinase activity | positive regulation of homotypic cell-cell adhesion | positive regulation of tissue remodeling | regulation of developmental process | regulation of ion transport | developmental process | positive regulation of anion transport | cellular protein modification process | positive regulation of prostaglandin secretion | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | regulation of fatty acid transport | positive regulation of bone resorption | positive regulation of nucleic acid-templated transcription | ERK1 and ERK2 cascade | positive regulation of transcription by RNA polymerase II | regulation of anion transport | positive regulation of JUN kinase activity | positive regulation of metabolic process | ossification | skeletal system development | positive regulation of lipid transport | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | response to tumor necrosis factor | positive regulation of osteoclast development | cellular response to organic substance | activation of JUN kinase activity | regulation of inflammatory response | chemotaxis | divalent inorganic cation homeostasis | positive regulation of leukocyte cell-cell adhesion | tooth eruption | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of signaling | signal transduction | mononuclear cell migration | regulation of signaling | positive regulation of fatty acid transport | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | cell | intrinsic component of membrane | cytoplasm | plasma membrane | integral component of plasma membrane | extracellular region | extracellular space | cell periphery | intracellular | membrane | intrinsic component of plasma membrane